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dc.contributor.authorContreras, Cristinaen_US
dc.contributor.authorGonzalez, Franciscoen_US
dc.contributor.authorFernø, Johanen_US
dc.contributor.authorDiéguez, Carlosen_US
dc.contributor.authorRahmouni, Kamalen_US
dc.contributor.authorNogueiras, Rubénen_US
dc.contributor.authorLópez, Miguelen_US
dc.PublishedAnnals of Medicine 2015, 47(2):150-168eng
dc.description.abstractBrown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process required for maintaining body temperature. BAT is regulated by the sympathetic nervous system (SNS), which activates lipolysis and mitochondrial uncoupling in brown adipocytes. For many years, BAT was considered to be important only in small mammals and newborn humans, but recent data have shown that BAT is also functional in adult humans. On the basis of this evidence, extensive research has been focused on BAT function, where new molecules, such as irisin and bone morphogenetic proteins, particularly BMP7 and BMP8B, as well as novel central factors and new regulatory mechanisms, such as orexins and the canonical ventomedial nucleus of the hypothalamus (VMH) AMP- activated protein kinase (AMPK)–SNS–BAT axis, have been discovered and emerged as potential drug targets to combat obesity. In this review we provide an overview of the complex central regulation of BAT and how different neuronal cell populations co-ordinately work to maintain energy homeostasis.en_US
dc.publisherTaylor & Franciseng
dc.rightsAttribution CC BY-NC-NDeng
dc.subjectβ -adrenoreceptorseng
dc.subjectbrown adipose tissue (BAT)eng
dc.subjectsympathetic nervous system (SNS)eng
dc.subjectthyroid hormoneeng
dc.subjectuncoupling protein 1 (UCP1)eng
dc.titleThe brain and brown faten_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 the authors
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi : 715
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical microbiology: 715
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Neurology: 752

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