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dc.contributor.authorZayats, Tetyanaen_US
dc.contributor.authorJohansson, Stefanen_US
dc.contributor.authorHaavik, Janen_US
dc.PublishedBehavioral and Brain Functions. 2015 Oct 16;11(1):33eng
dc.description.abstractGenome-wide association (GWA) studies have shown that many different genetic variants cumulatively contribute to the risk of psychiatric disorders. It has also been demonstrated that various parent-of-origin effects (POE) may differentially influence the risk of these disorders. Together, these observations have provided important new possibilities to uncover the genetic underpinnings of such complex phenotypes. As POE so far have received little attention in neuropsychiatric disorders, there is still much progress to be made. Here, we mainly focus on the new and emerging role of POE in attention-deficit hyperactivity disorder (ADHD). We review the current evidence that POE play an imperative role in vulnerability to ADHD and related disorders. We also discuss how POE can be assessed using statistical genetics tools, expanding the resources of modern psychiatric genetics. We propose that better comprehension and inspection of POE may offer new insight into the molecular basis of ADHD and related phenotypes, as well as the potential for preventive and therapeutic interventions.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BY 4.0eng
dc.subjectParent-of-origin effectseng
dc.subjectMaternal effectseng
dc.subjectMitochondrial DNAeng
dc.subjectSex chromosomeseng
dc.titleExpanding the toolbox of ADHD genetics. How can we make sense of parent of origin effects in ADHD and related behavioral phenotypes?en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2015 Zayats et al.
dc.subject.nsiVDP::Medisinske Fag: 700en_US

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Attribution CC BY 4.0
Except where otherwise noted, this item's license is described as Attribution CC BY 4.0