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dc.contributor.authorNæsgaard, Patrycjaen_US
dc.contributor.authorFuente, Ricardo León de laen_US
dc.contributor.authorNilsen, Stein Toreen_US
dc.contributor.authorWoie, Leiken_US
dc.contributor.authorÅrsland, Torbjørnen_US
dc.contributor.authorStaines, Harryen_US
dc.contributor.authorNilsen, Dennis W.T.en_US
dc.PublishedCardiology Research and Practice 2013, 2013:398034eng
dc.description.abstractVitamin D may not only reflect disease but may also serve as a prognostic indicator. Our aim was to assess the gender-specific utility of vitamin D measured as 25-hydroxy-vitamin D [25(OH)D] to predict all-cause and cardiac death in patients with suspected acute coronary syndrome (ACS) and to compare its prognostic utility to brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hsCRP). Blood samples were harvested on admission in 982 patients. Forty percent were women (65.9 ± 12.6 years). Mortality was evaluated in quartiles of 25(OH)D, BNP, and hsCRP, respectively, during a 5-year follow-up, applying univariate and multivariate analyses. One hundred and seventy-three patients died; 78 were women. In 92 patients (37 women), death was defined as cardiac. In women, the univariate hazard ratio (HR) for total death of 25(OH)D in Quartile (Q) 2 versus Q1, Q3 versus Q1, and Q4 versus Q1 was 0.55 (95% CI 0.33–0.93), 0.29 (95% CI 0.15–0.55), and 0.13 (95% CI 0.06–0.32), respectively. In females, it was an independent predictor of total and cardiac death, whereas BNP and hsCRP were less gender-specific. No gender differences in 25(OH)D were noted in a reference material. Accordingly, vitamin D independently predicts mortality in females with suspected ACS.en_US
dc.rightsAttribution CC BYeng
dc.titleVitamin D predicts all-cause and cardiac mortality in females with suspected acute coronary syndrome: a comparison with brain natriuretic peptide and high-sensitivity C-reactive proteinen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2013 The Authors
dc.relation.projectEgen institusjon: Identifier: NCT01377402
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Cardiology: 771

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