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dc.contributor.authorMyrum, Craigen_US
dc.contributor.authorNikolaienko, Oleksiien_US
dc.contributor.authorBramham, Clive R.en_US
dc.contributor.authorHaavik, Janen_US
dc.contributor.authorZayats, Tetyanaen_US
dc.PublishedMyrum C, Nikolaienko O, Bramham CRE, Haavik J, Zayats T. Implication of the APP gene in intellectual abilities. Journal of Alzheimer's Disease. 2017;59(2):723-735eng
dc.description.abstractBackground: Cognitive functions are highly heritable and polygenic, though the source of this genetic influence is unclear. On the neurobiological level, these functions rely on effective neuroplasticity, in which the activity-regulated cytoskeleton associated protein (ARC) plays an essential role. Objectives: To examine whether the ARC gene complex may contribute to the genetic components of intellectual function given the crucial role of ARC in brain plasticity and memory formation. Methods: The ARC complex was tested for association with intelligence (IQ) in children from the Avon Longitudinal Study of Parents and Children (ALSPAC, N = 5,165). As Alzheimer’s disease (AD) shares genetics with cognitive functioning, the association was followed up in an AD sample (17,008 cases, 37,154 controls). Results: The ARC complex revealed association with verbal and total IQ (empirical p = 0.027 and 0.041, respectively) in the ALSPAC. The strongest single variant signal (rs2830077; empirical p = 0.018), within the APP gene, was confirmed in the AD sample (p = 2.76E-03). Functional analyses of this variant showed its preferential binding to the transcription factor CP2. Discussion: This study implicates APP in childhood IQ. While follow-up studies are needed, this observation could help elucidate the etiology of disorders associated with cognitive dysfunction, such as AD.en_US
dc.publisherIOS Presseng
dc.rightsAttribution CC BY-NCeng
dc.subjectAlzheimer’s diseaseeng
dc.subjectAvon Longitudinal Study of Parents and Childreneng
dc.subjectsynaptic plasticityeng
dc.titleImplication of the APP gene in intellectual abilitiesen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2017 IOS Press and the authors
dc.source.journalJournal of Alzheimer's Disease

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