“Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited”
| dc.contributor.author | Brix, Maiken Kirkegaard | en_US |
| dc.contributor.author | Ersland, Lars | en_US |
| dc.contributor.author | Hugdahl, Kenneth | en_US |
| dc.contributor.author | Grüner, Renate | en_US |
| dc.contributor.author | Posserud, Maj-Britt | en_US |
| dc.contributor.author | Hammar, Åse | en_US |
| dc.contributor.author | Craven, Alexander R. | en_US |
| dc.contributor.author | Noeske, Ralph | en_US |
| dc.contributor.author | Evans, C. John | en_US |
| dc.contributor.author | Walker, Hanne B. | en_US |
| dc.contributor.author | Midtvedt, Tore | en_US |
| dc.contributor.author | Beyer, Mona K. | en_US |
| dc.date.accessioned | 2018-08-07T12:45:12Z | |
| dc.date.available | 2018-08-07T12:45:12Z | |
| dc.date.issued | 2015-06-22 | |
| dc.identifier.issn | 1662-453X | |
| dc.identifier.issn | 1662-4548 | |
| dc.identifier.uri | https://hdl.handle.net/1956/18023 | |
| dc.description.abstract | Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels. | en_US |
| dc.language.iso | eng | eng |
| dc.publisher | Frontiers | eng |
| dc.relation.ispartof | <a href="http://hdl.handle.net/1956/18019" target="blank">Establishing reliable MR spectroscopy techniques for measuring GABA and Glutathione in the human brain</a> | |
| dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | eng |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | eng |
| dc.title | “Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited” | en_US |
| dc.type | Peer reviewed | |
| dc.type | Journal article | |
| dc.description.version | publishedVersion | en_US |
| dc.rights.holder | Copyright 2015 Brix, Ersland, Hugdahl, Grüner, Posserud, Hammar, Craven, Noeske, Evans, Walker, Midtvedt and Beyer. | |
| dc.source.articlenumber | 365 | |
| dc.identifier.doi | https://doi.org/10.3389/fnhum.2015.00365 | |
| dc.source.journal | Frontiers in Human Neuroscience | |
| dc.source.40 | 9 | |
| dc.subject.nsi | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Radiologi og bildediagnostikk: 763 | en_US |
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