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dc.contributor.authorBrix, Maiken Kirkegaarden_US
dc.contributor.authorErsland, Larsen_US
dc.contributor.authorHugdahl, Kennethen_US
dc.contributor.authorGrüner, Renateen_US
dc.contributor.authorPosserud, Maj-Britten_US
dc.contributor.authorHammar, Åseen_US
dc.contributor.authorCraven, Alexander R.en_US
dc.contributor.authorNoeske, Ralphen_US
dc.contributor.authorEvans, C. Johnen_US
dc.contributor.authorWalker, Hanne B.en_US
dc.contributor.authorMidtvedt, Toreen_US
dc.contributor.authorBeyer, Mona K.en_US
dc.date.accessioned2018-08-07T12:45:12Z
dc.date.available2018-08-07T12:45:12Z
dc.date.issued2015-06-22
dc.identifier.issn1662-453X
dc.identifier.issn1662-4548
dc.identifier.urihttps://hdl.handle.net/1956/18023
dc.description.abstractMagnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.en_US
dc.language.isoengeng
dc.publisherFrontierseng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/18019" target="blank">Establishing reliable MR spectroscopy techniques for measuring GABA and Glutathione in the human brain</a>
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.eng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.title“Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited”en_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 Brix, Ersland, Hugdahl, Grüner, Posserud, Hammar, Craven, Noeske, Evans, Walker, Midtvedt and Beyer.
dc.source.articlenumber365
dc.identifier.doihttps://doi.org/10.3389/fnhum.2015.00365
dc.source.journalFrontiers in Human Neuroscience
dc.source.409
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Radiologi og bildediagnostikk: 763en_US


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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.