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dc.contributor.authorTvedt, Tor Henrik Andersonen_US
dc.contributor.authorMelve, Guro Kristinen_US
dc.contributor.authorTsykunova, Galinaen_US
dc.contributor.authorAhmed, Aymen Ben_US
dc.contributor.authorBrenner, Annetteen_US
dc.contributor.authorBruserud, Øysteinen_US
dc.PublishedTvedt THA, Melve GK, Tsykunova G, Ahmed AB, Brenner AK, Bruserud Ø. Immunological heterogeneity of healthy peripheral blood stem cell donors - Effects of granulocyte colony-stimulating factor on inflammatory responses. International Journal of Molecular Sciences. 2018;19(10):2886eng
dc.description.abstractInterleukin-6 (IL-6) contributes to the development of immune-mediated complications after allogeneic stem cell transplantation. However, systemic IL-6 levels also increase during granulocyte colony-stimulating factor (G-CSF) mobilization of hematopoietic stem cells in healthy donors, but it is not known whether this mobilization alters systemic levels of other IL-6 family cytokines/receptors and whether such effects differ between donors. We examined how G-CSF administration influenced C-reactive protein (CRP) levels (85 donors) and serum levels of IL-6 family cytokines/receptors (20 donors). G-CSF increased CRP levels especially in elderly donors with high pretherapy levels, but these preharvesting levels did not influence clinical outcomes (nonrelapse mortality, graft versus host disease). The increased IL-6 levels during G-CSF therapy normalized within 24 h after treatment. G-CSF administration did not alter serum levels of other IL-6-familly mediators. Oncostatin M, but not IL-6, showed a significant correlation with CRP levels during G-CSF therapy. Clustering analysis of mediator levels during G-CSF administration identified two donor subsets mainly characterized by high oncostatin M and IL-6 levels, respectively. Finally, G-CSF could increase IL-6 release by in vitro cultured monocytes, fibroblasts, and mesenchymal stem cells. In summary, G-CSF seems to induce an acute phase reaction with increased systemic IL-6 levels in healthy stem cell donors.en_US
dc.rightsAttribution CC BYeng
dc.subjecttoll-like receptorseng
dc.subjectC-reactive proteineng
dc.subjectacute-phase reactioneng
dc.subjectgraft versus host diseaseeng
dc.subjecttissue and organ procurementeng
dc.titleImmunological heterogeneity of healthy peripheral blood stem cell donors - Effects of granulocyte colony-stimulating factor on inflammatory responsesen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s)
dc.source.journalInternational Journal of Molecular Sciences

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