Identification of nine new susceptibility loci for endometrial cancer
| dc.contributor.author | O'Mara, Tracy A. | en_US |
| dc.contributor.author | Glubb, Dylan M. | en_US |
| dc.contributor.author | Amant, Frédéric | en_US |
| dc.contributor.author | Annibali, Daniela | en_US |
| dc.contributor.author | Ashton, Katie | en_US |
| dc.contributor.author | Attia, John | en_US |
| dc.contributor.author | Auer, Paul L. | en_US |
| dc.contributor.author | Beckmann, Matthias W. | en_US |
| dc.contributor.author | Black, Amanda | en_US |
| dc.contributor.author | Bolla, Manjeet K. | en_US |
| dc.contributor.author | Brauch, Hiltrud | en_US |
| dc.contributor.author | Brenner, Hermann | en_US |
| dc.contributor.author | Brinton, Louise | en_US |
| dc.contributor.author | Buchanan, Daniel D. | en_US |
| dc.contributor.author | Burwinkel, Barbara | en_US |
| dc.contributor.author | Chang-Claude, Jenny | en_US |
| dc.contributor.author | Chanock, Stephen J. | en_US |
| dc.contributor.author | Chen, Chu | en_US |
| dc.contributor.author | Chen, Maxine M. | en_US |
| dc.contributor.author | Cheng, Timothy H.T. | en_US |
| dc.contributor.author | Clarke, Christine L. | en_US |
| dc.contributor.author | Clendenning, Mark | en_US |
| dc.contributor.author | Cook, Linda S. | en_US |
| dc.contributor.author | Couch, Fergus J. | en_US |
| dc.contributor.author | Cox, Angela | en_US |
| dc.contributor.author | Crous-Bous, Marta | en_US |
| dc.contributor.author | Czene, Kamila | en_US |
| dc.contributor.author | Day, Felix | en_US |
| dc.contributor.author | Dennis, Joe | en_US |
| dc.contributor.author | Depreeuw, Jeroen | en_US |
| dc.contributor.author | Doherty, Jennifer Anne | en_US |
| dc.contributor.author | Dörk, Thilo | en_US |
| dc.contributor.author | Dowdy, Sean C. | en_US |
| dc.contributor.author | Dürst, Matthias | en_US |
| dc.contributor.author | Ekici, Arif B. | en_US |
| dc.contributor.author | Fasching, Peter A. | en_US |
| dc.contributor.author | Fridley, Brooke L. | en_US |
| dc.contributor.author | Friedenreich, Christine M. | en_US |
| dc.contributor.author | Fritschi, Lin | en_US |
| dc.contributor.author | Fung, Jenny | en_US |
| dc.contributor.author | García-Closas, Montserrat | en_US |
| dc.contributor.author | Gaudet, Mia M. | en_US |
| dc.contributor.author | Giles, Graham G. | en_US |
| dc.contributor.author | Goode, Ellen L. | en_US |
| dc.contributor.author | Gorman, Maggie | en_US |
| dc.contributor.author | Haiman, Christopher A. | en_US |
| dc.contributor.author | Hall, Per | en_US |
| dc.contributor.author | Hankison, Susan E. | en_US |
| dc.contributor.author | Healey, Catherine S. | en_US |
| dc.contributor.author | Hein, Alexander | en_US |
| dc.contributor.author | Hillemanns, Peter | en_US |
| dc.contributor.author | Hodgson, Shirley | en_US |
| dc.contributor.author | Høivik, Erling Andre | en_US |
| dc.contributor.author | Holliday, Elizabeth G. | en_US |
| dc.contributor.author | Hopper, John L. | en_US |
| dc.contributor.author | Hunter, David J. | en_US |
| dc.contributor.author | Jones, Angela | en_US |
| dc.contributor.author | Krakstad, Camilla | en_US |
| dc.contributor.author | Kristensen, Vessela N. | en_US |
| dc.contributor.author | Lambrechts, Diether | en_US |
| dc.contributor.author | Marchand, Loic Le | en_US |
| dc.contributor.author | Liang, Xiaolin | en_US |
| dc.contributor.author | Lindblom, Annika | en_US |
| dc.contributor.author | Lissowska, Jolanta | en_US |
| dc.contributor.author | Long, Jirong | en_US |
| dc.contributor.author | Lu, Lingeng | en_US |
| dc.contributor.author | Magliocco, Anthony M. | en_US |
| dc.contributor.author | Martin, Lynn | en_US |
| dc.contributor.author | McEvoy, Mark | en_US |
| dc.contributor.author | Meindl, Alfons | en_US |
| dc.contributor.author | Michailidou, Kyriaki | en_US |
| dc.contributor.author | Milne, Roger L. | en_US |
| dc.contributor.author | Mints, Miriam | en_US |
| dc.contributor.author | Montgomery, Grant W. | en_US |
| dc.contributor.author | Nassir, Rami | en_US |
| dc.contributor.author | Olsson, Håkan | en_US |
| dc.contributor.author | Orlow, Irene | en_US |
| dc.contributor.author | Otton, Geoffrey | en_US |
| dc.contributor.author | Palles, Claire | en_US |
| dc.contributor.author | Perry, John R.B. | en_US |
| dc.contributor.author | Peto, Julian | en_US |
| dc.contributor.author | Pooler, Loreall | en_US |
| dc.contributor.author | Prescott, Jennifer | en_US |
| dc.contributor.author | Proietto, Tony | en_US |
| dc.contributor.author | Rebbeck, Timothy R. | en_US |
| dc.contributor.author | Risch, Harvey A. | en_US |
| dc.contributor.author | Rogers, Peter A.W. | en_US |
| dc.contributor.author | Rübner, Matthias | en_US |
| dc.contributor.author | Runnebaum, Ingo | en_US |
| dc.contributor.author | Sacerdote, Carlotta | en_US |
| dc.contributor.author | Sarto, Gloria E. | en_US |
| dc.contributor.author | Schumacher, Fredrick | en_US |
| dc.contributor.author | Scott, Rodney J. | en_US |
| dc.contributor.author | Setiawan, V. Wendy | en_US |
| dc.contributor.author | Shah, Mitul | en_US |
| dc.contributor.author | Sheng, Xin | en_US |
| dc.contributor.author | Shu, Xiao-Ou | en_US |
| dc.contributor.author | Southey, Melissa C. | en_US |
| dc.contributor.author | Swerdlow, Anthony J. | en_US |
| dc.contributor.author | Tham, Emma | en_US |
| dc.contributor.author | Trovik, Jone | en_US |
| dc.contributor.author | Turman, Constance | en_US |
| dc.contributor.author | Tyrer, Jonathan P. | en_US |
| dc.contributor.author | Vachon, Celine | en_US |
| dc.contributor.author | VanDen Berg, David | en_US |
| dc.contributor.author | Vanderstichele, Adriaan | en_US |
| dc.contributor.author | Wang, Zhaoming | en_US |
| dc.contributor.author | Webb, Penelope M. | en_US |
| dc.contributor.author | Wentzensen, Nicolas | en_US |
| dc.contributor.author | Werner, Henrica Maria Johanna | en_US |
| dc.contributor.author | Winham, Stacey J. | en_US |
| dc.contributor.author | Wolk, Alicja | en_US |
| dc.contributor.author | Xia, Lucy | en_US |
| dc.contributor.author | Xiang, Yong-Bing | en_US |
| dc.contributor.author | Yang, Hannah P. | en_US |
| dc.contributor.author | Yu, Herbert | en_US |
| dc.contributor.author | Zheng, Wei | en_US |
| dc.contributor.author | Pharoah, Paul D.P. | en_US |
| dc.contributor.author | Dunning, Alison M. | en_US |
| dc.contributor.author | Kraft, Peter | en_US |
| dc.contributor.author | De Vivo, Immaculata | en_US |
| dc.contributor.author | Tomlinson, Ian | en_US |
| dc.contributor.author | Easton, Douglas F. | en_US |
| dc.contributor.author | Spurdle, Amanda B. | en_US |
| dc.contributor.author | Thompson, Deborah J. | en_US |
| dc.date.accessioned | 2019-06-07T09:22:04Z | |
| dc.date.available | 2019-06-07T09:22:04Z | |
| dc.date.issued | 2018-08-09 | |
| dc.Published | O'Mara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann MW, Black A, Bolla MK, Brauch H, Brenner H, Brinton L, Buchanan DD, Burwinkel B, Chang-Claude J, Chanock SJ, Chen C, Chen, Cheng TH, Clarke CL, Clendenning, Cook LS, Couch FJ, Cox A, Crous-Bous, Czene K, Day, Dennis J, Depreeuw J, Doherty JA, Dörk T, Dowdy SC, Dürst M, Ekici AB, Fasching PA, Fridley BL, Friedenreich, Fritschi L, Fung, García-Closas M, Gaudet MM, Giles GG, Goode EL, Gorman M, Haiman CA, Hall P, Hankison, Healey CS, Hein A, Hillemanns P, Hodgson S, Høivik EA, Holliday EG, Hopper JL, Hunter DJ, Jones A, Krakstad C, Kristensen VN, Lambrechts D, Marchand LL, Liang X, Lindblom A, Lissowska J, Long J, Lu L, Magliocco AM, Martin L, McEvoy M, Meindl A, Michailidou K, Milne RL, Mints M, Montgomery GW, Nassir, Olsson H, Orlow I, Otton G, Palles C, Perry JR, Peto J, Pooler, Prescott J, Proietto T, Rebbeck TR, Risch HA, Rogers, Rübner M, Runnebaum I, Sacerdote C, Sarto, Schumacher F, Scott RJ, Setiawan VW, Shah M, Sheng, Shu X, Southey MC, Swerdlow AJ, Tham E, Trovik J, Turman C, Tyrer JP, Vachon C, VanDen Berg, Vanderstichele A, Wang Z, Webb PM, Wentzensen N, Werner HMJ, Winham SJ, Wolk A, Xia L, Xiang Y, Yang HP, Yu H, Zheng W, Pharoah PD, Dunning AM, Kraft P, De Vivo I, Tomlinson I, Easton DF, Spurdle AB, Thompson DJ. Identification of nine new susceptibility loci for endometrial cancer. Nature Communications. 2018;9:3166 | eng |
| dc.identifier.issn | 2041-1723 | |
| dc.identifier.uri | https://hdl.handle.net/1956/19910 | |
| dc.description.abstract | Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study. | en_US |
| dc.language.iso | eng | eng |
| dc.publisher | Springer Nature | eng |
| dc.rights | Attribution CC BY | eng |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
| dc.title | Identification of nine new susceptibility loci for endometrial cancer | en_US |
| dc.type | Peer reviewed | |
| dc.type | Journal article | |
| dc.date.updated | 2019-03-20T14:54:59Z | |
| dc.description.version | publishedVersion | en_US |
| dc.rights.holder | Copyright 2018 The Author(s) | |
| dc.identifier.doi | https://doi.org/10.1038/s41467-018-05427-7 | |
| dc.identifier.cristin | 1611959 | |
| dc.source.journal | Nature Communications |
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