dc.contributor.author | Omsland, Maria | en_US |
dc.contributor.author | Pise-Masison, Cynthia A. | en_US |
dc.contributor.author | Fujikawa, Dai | en_US |
dc.contributor.author | Galli, Veronica | en_US |
dc.contributor.author | Fenizia, Claudio | en_US |
dc.contributor.author | Parks, Robyn Washington | en_US |
dc.contributor.author | Gjertsen, Bjørn Tore | en_US |
dc.contributor.author | Franchini, Genoveffa | en_US |
dc.contributor.author | Andresen, Vibeke | en_US |
dc.date.accessioned | 2019-07-05T13:51:31Z | |
dc.date.available | 2019-07-05T13:51:31Z | |
dc.date.issued | 2018-07-24 | |
dc.Published | Omsland M, Pise-Masison CA, Fujikawa, Galli V, Fenizia, Parks RW, Gjertsen BT, Franchini G, Andresen V. Inhibition of tunneling nanotube (TNT) formation and Human T-cell leukemia virus type 1 (HTLV-1) transmission by cytarabine. Scientific Reports. 2018;8:11118 | eng |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://hdl.handle.net/1956/20571 | |
dc.description.abstract | The human T-cell leukemia virus type 1 (HTLV-1) is highly dependent on cell-to-cell interaction for transmission and productive infection. Cell-to-cell interactions through the virological synapse, bioflm-like structures and cellular conduits have been reported, but the relative contribution of each mechanism on HTLV-1 transmission still remains vastly unknown. The HTLV-1 protein p8 has been found to increase viral transmission and cellular conduits. Here we show that HTLV-1 expressing cells are interconnected by tunneling nanotubes (TNTs) defned as thin structures containing F-actin and lack of tubulin connecting two cells. TNTs connected HTLV-1 expressing cells and uninfected T-cells and monocytes and the viral proteins Tax and Gag localized to these TNTs. The HTLV-1 expressing protein p8 was found to induce TNT formation. Treatment of MT-2 cells with the nucleoside analog cytarabine (cytosine arabinoside, AraC) reduced number of TNTs and furthermore reduced TNT formation induced by the p8 protein. Intercellular transmission of HTLV-1 through TNTs provides a means of escape from recognition by the immune system. Cytarabine could represent a novel anti-HTLV-1 drug interfering with viral transmission. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Nature Research | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.title | Inhibition of tunneling nanotube (TNT) formation and Human T-cell leukemia virus type 1 (HTLV-1) transmission by cytarabine | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2019-01-24T11:24:28Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2018 The Authors | |
dc.identifier.doi | https://doi.org/10.1038/s41598-018-29391-w | |
dc.identifier.cristin | 1603569 | |
dc.source.journal | Scientific Reports | |