dc.contributor.author | Dhillon, Amandeep Kaur | en_US |
dc.contributor.author | Kremer, Andreas E. | en_US |
dc.contributor.author | Kummen, Martin | en_US |
dc.contributor.author | Boberg, Kirsten Muri | en_US |
dc.contributor.author | Elferink, Ronald P. Oude | en_US |
dc.contributor.author | Karlsen, Tom Hemming | en_US |
dc.contributor.author | Beuers, Ulrich | en_US |
dc.contributor.author | Vesterhus, Mette | en_US |
dc.contributor.author | Hov, Johannes Espolin Roksund | en_US |
dc.date.accessioned | 2019-09-03T13:03:34Z | |
dc.date.available | 2019-09-03T13:03:34Z | |
dc.date.issued | 2019-06-11 | |
dc.Published | Dhillon AK, Kremer, Kummen M, Boberg KM, Elferink, Karlsen HT, Beuers U, Vesterhus M, Hov JR. Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports. 2019;9:8450. | eng |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://hdl.handle.net/1956/20800 | |
dc.description.abstract | Autotaxin has been associated with liver disease severity and transplant-free survival. This study aimed to validate autotaxin as a biomarker in two cohorts of Norwegian large-duct PSC patients, one discovery panel (n=165) and one validation panel (n=87). Serum activity of autotaxin was measured in diluted sera by a fuorometric enzymatic assay. Patients reaching an end-point, liver transplantation or death, (discovery panel: n=118 [71.5%]; validation panel: n=35 [40.2%]), showed higher autotaxin activity compared with the other patients, P<0.001 and P=0.004, respectively. Kaplan-Meier survival analyses showed a strong association between increasing autotaxin activity and shorter liver transplant-free survival (discovery panel: P<0.001, validation panel: P=0.001). There was no relationship between autotaxin activity and the presence of infammatory bowel disease or occurrence of hepatobiliary malignancy. In a multivariable analysis, high autotaxin activity was associated with an increased risk of liver transplantation or death (hazard ratio 2.03 (95% confdence interval 1.21–3.40), P<0.01), independent from Mayo risk score, an in-house enhanced liver fbrosis score and interleukin-8 in serum. In conclusion, increased serum autotaxin activity is associated with reduced liver transplantfree survival independent from Mayo risk score and markers of infammation and fbrosis. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Nature Research | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.title | Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2019-08-05T12:02:34Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright The Author(s) 2019 | |
dc.identifier.doi | https://doi.org/10.1038/s41598-019-44762-7 | |
dc.identifier.cristin | 1711332 | |
dc.source.journal | Scientific Reports | |