dc.contributor.author | Aliko, Ardita | en_US |
dc.contributor.author | Kaminska, Marta | en_US |
dc.contributor.author | Falkowski, Katherine | en_US |
dc.contributor.author | Bielecka, Ewa | en_US |
dc.contributor.author | Benedyk-Machaczka, Malgorzata | en_US |
dc.contributor.author | Malicki, Stanislaw | en_US |
dc.contributor.author | Koziel, Joanna | en_US |
dc.contributor.author | Wong, Alicia | en_US |
dc.contributor.author | Bryzek, Danuta | en_US |
dc.contributor.author | Kantyka, Tomasz Tadeusz | en_US |
dc.contributor.author | Mydel, Piotr Mateusz | en_US |
dc.date.accessioned | 2020-03-13T12:31:17Z | |
dc.date.available | 2020-03-13T12:31:17Z | |
dc.date.issued | 2019 | |
dc.Published | Aliko A, Kaminska M, Falkowski K, Bielecka E, Benedyk-Machaczka, Malicki S, Koziel J, Wong A, Bryzek D, Kantyka TT, Mydel PM. Discovery of novel potential reversible peptidyl arginine deiminase inhibitor. International Journal of Molecular Sciences. 2019;20(9):2174 | eng |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | https://hdl.handle.net/1956/21489 | |
dc.description.abstract | Citrullination, a posttranslational modification, is catalyzed by peptidylarginine deiminases (PADs), a unique family of enzymes that converts peptidyl-arginine to peptidyl-citrulline. Overexpression and/or increased PAD activity is observed in rheumatoid arthritis (RA), Alzheimer’s disease, multiple sclerosis, and cancer. Moreover, bacterial PADs, such as Porphyromonas gingivalis PAD (PPAD), may have a role in the pathogenesis of RA, indicating PADs as promising therapeutic targets. Herein, six novel compounds were examined as potential inhibitors of human PAD4 and PPAD, and compared to an irreversible PAD inhibitor, Cl-amidine. Four of the tested compounds (compounds 2, 3, 4, and 6) exhibited a micromolar-range inhibition potency against PAD4 and no effect against PPAD in the in vitro assays. Compound 4 was able to inhibit the PAD4-induced citrullination of H3 histone with higher efficiency than Cl-amidine. In conclusion, compound 4 was highly effective and presents a promising direction in the search for novel RA treatment strategies. | en_US |
dc.language.iso | eng | eng |
dc.publisher | MDPI | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.title | Discovery of novel potential reversible peptidyl arginine deiminase inhibitor | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2020-01-21T16:49:19Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2019 The Author(s) | |
dc.identifier.doi | https://doi.org/10.3390/ijms20092174 | |
dc.identifier.cristin | 1726146 | |
dc.source.journal | International Journal of Molecular Sciences | |