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dc.contributor.authorPavlou, Maria Angeliki S.en_US
dc.contributor.authorGrandbarbe, Lucen_US
dc.contributor.authorBuckley, Noel J.en_US
dc.contributor.authorNiclou, Simone Pierretteen_US
dc.contributor.authorMichelucci, Alessandroen_US
dc.PublishedPavlou MAS, Grandbarbe L, Buckley NJ, Niclou SP, Michelucci A. Transcriptional and epigenetic mechanisms underlying astrocyte identity. Progress in Neurobiology. 2019;174:36-52eng
dc.description.abstractAstrocytes play a significant role in coordinating neural development and provide critical support for the function of the CNS. They possess important adaptation capacities that range from their transition towards reactive astrocytes to their ability to undergo reprogramming, thereby revealing their potential to retain latent features of neural progenitor cells. We propose that the mechanisms underlying reactive astrogliosis or astrocyte reprogramming provide an opportunity for initiating neuronal regeneration, a process that is notably reduced in the mammalian nervous system throughout evolution. Conversely, this plasticity may also affect normal astrocytic functions resulting in pathologies ranging from neurodevelopmental disorders to neurodegenerative diseases and brain tumors. We postulate that epigenetic mechanisms linking extrinsic cues and intrinsic transcriptional programs are key factors to maintain astrocyte identity and function, and critically, to control the balance of regenerative and degenerative activity. Here, we will review the main evidences supporting this concept. We propose that unravelling the epigenetic and transcriptional mechanisms underlying the acquisition of astrocyte identity and plasticity, as well as understanding how these processes are modulated by the local microenvironment under specific threatening or pathological conditions, may pave the way to new therapeutic avenues for several neurological disorders including neurodegenerative diseases and brain tumors of astrocytic lineage.en_US
dc.publisherElsevier Ltdeng
dc.rightsAttribution CC BY-NC-NDeng
dc.subjectTranscriptional mechanismseng
dc.subjectEpigenetic modificationseng
dc.subjectAstrocyte differentiationeng
dc.subjectReactive astrogliosiseng
dc.titleTranscriptional and epigenetic mechanisms underlying astrocyte identityen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalProgress in Neurobiology

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