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dc.contributor.authorBarstad, Bjørnen_US
dc.contributor.authorTveitnes, Dagen_US
dc.contributor.authorDalen, Ingvilden_US
dc.contributor.authorNoraas, Sølvien_US
dc.contributor.authorAsk, Ingvilden_US
dc.contributor.authorBosse, Franziskus Johannesen_US
dc.contributor.authorØymar, Knuten_US
dc.date.accessioned2020-04-22T11:50:42Z
dc.date.available2020-04-22T11:50:42Z
dc.date.issued2019
dc.PublishedBarstad B, Tveitnes D, Dalen I, Noraas S, Ask I, Bosse FJ, Øymar K. The B-lymphocyte chemokine CXCL13 in the cerebrospinal fluid of children with Lyme neuroborreliosis: associations with clinical and laboratory variables. Infectious Diseases. 2019;51(11-12):856-863eng
dc.identifier.issn2374-4235
dc.identifier.issn2374-4243
dc.identifier.urihttps://hdl.handle.net/1956/21973
dc.descriptionUnder embargo until: 2020-10-01en_US
dc.description.abstractBackground: The B-lymphocyte chemokine CXCL13 is increasingly considered as a useful early phase diagnostic marker of Lyme neuroborreliosis (LNB). However, the large variation in level of CXCL13 in the cerebrospinal fluid (CSF) observed in LNB patients is still unexplained. We aimed to identify factors associated with the level of CXCL13 in children with LNB, possibly improving the interpretation of CXCL13 as a diagnostic marker of LNB. Methods: Children with confirmed and probable LNB were included in a prospective study on CXCL13 in CSF as a diagnostic marker of LNB. The variables age, sex, facial nerve palsy, generalized inflammation symptoms (fever, headache, neck-stiffness and/or fatigue), duration of symptoms, Borrelia antibodies in CSF, Borrelia antibody index (AI), CSF white blood cells (WBC), CSF protein and detection of the genospecies Borrelia garinii by PCR were included in simple and multivariable regression analyses to study the associations with the CXCL13 level. Results: We included 53 children with confirmed and 17 children with probable LNB. CXCL13 levels in CSF were positively associated with WBC, protein and Borrelia antibodies in CSF in both simple and multivariable analyses. We did not find any associations between CXCL13 and age, sex, clinical symptoms, duration of symptoms, AI or the detection of Borrelia garinii. Conclusions: High levels of CSF CXCL13 are present in the early phase of LNB and correlate with the level of CSF WBC and protein. Our results indicate that CSF CXCL13 in children evaluated for LNB can be interpreted independently of clinical features or duration of symptoms.en_US
dc.language.isoengeng
dc.publisherTaylor & Franciseng
dc.titleThe B-lymphocyte chemokine CXCL13 in the cerebrospinal fluid of children with Lyme neuroborreliosis: associations with clinical and laboratory variablesen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2020-01-27T11:53:54Z
dc.description.versionacceptedVersionen_US
dc.rights.holderCopyright 2019 Society for Scandinavian Journal of Infectious Diseases
dc.identifier.doihttps://doi.org/10.1080/23744235.2019.1671988
dc.identifier.cristin1745755
dc.source.journalInfectious Diseases


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