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dc.contributor.authorFeng, Zichaoen_US
dc.contributor.authorZhou, Wenjingen_US
dc.contributor.authorWang, Jiweien_US
dc.contributor.authorQi, Qichaoen_US
dc.contributor.authorHan, Mingzhien_US
dc.contributor.authorKong, Yangen_US
dc.contributor.authorHu, Yaotianen_US
dc.contributor.authorZhang, Yulinen_US
dc.contributor.authorChen, Anbinen_US
dc.contributor.authorHuang, Binen_US
dc.contributor.authorZhang, Dien_US
dc.contributor.authorLi, Wenjieen_US
dc.contributor.authorZhang, Qingen_US
dc.contributor.authorBjerkvig, Rolfen_US
dc.contributor.authorWang, Jianen_US
dc.contributor.authorThorsen, Fritsen_US
dc.contributor.authorLi, Xingangen_US
dc.PublishedFeng Z, Zhou W, Wang J, Qi Q, Han M, Kong Y, Hu, Zhang Y, Chen, Huang B, Zhang D, Li W, Zhang Q, Bjerkvig R, Wang J, Thorsen F, Li X. Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma.. Journal of Cellular and Molecular Medicine. 2019:24;5:2847-2856eng
dc.description.abstractProteolipid protein 2 (PLP2) is an integral ion channel membrane protein of the endoplasmic reticulum. The protein has been shown to be highly expressed in many cancer types, but its importance in glioma progression is poorly understood. Using publicly available datasets (Rembrandt, TCGA and CGGA), we found that the expression of PLP2 was significantly higher in high‐grade gliomas than in low‐grade gliomas. We confirmed these results at the protein level through IHC staining of high‐grade (n = 56) and low‐grade glioma biopsies (n = 16). Kaplan‐Meier analysis demonstrated that increased PLP2 expression was associated with poorer patient survival. In functional experiments, siRNA and shRNA PLP2 knockdown induced ER stress and increased apoptosis and autophagy in U87 and U251 glioma cell lines. Inhibition of autophagy with chloroquine augmented apoptotic cell death in U87‐ and U251‐siPLP2 cells. Finally, intracranial xenografts derived from U87‐ and U251‐shPLP2 cells revealed that loss of PLP2 reduced glioma growth in vivo. Our results therefore indicate that increased PLP2 expression promotes GBM growth and that PLP2 represents a potential future therapeutic target.en_US
dc.rightsAttribution CC BYeng
dc.titleReduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma.en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalJournal of Cellular and Molecular Medicine

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