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dc.contributor.authorSudfeld, Christopher R.
dc.contributor.authorManji, Karim P.
dc.contributor.authorDarling, Anne Marie
dc.contributor.authorKisenge, Rodrick
dc.contributor.authorKvestad, Ingrid
dc.contributor.authorHysing, Mari
dc.contributor.authorBelinger, David C.
dc.contributor.authorStrand, Tor A
dc.contributor.authorDuggan, Christopher P.
dc.contributor.authorFawzi, Wafaie W.
dc.date.accessioned2020-06-19T09:45:50Z
dc.date.available2020-06-19T09:45:50Z
dc.date.issued2019
dc.PublishedSudfeld, Manji KP, Darling AM, Kisenge, Kvestad I, Hysing M, Belinger, Strand TA, Duggan CP, Fawzi WW. Effect of antenatal and infant micronutrient supplementation on middle childhood and early adolescent development outcomes in Tanzania. European Journal of Clinical Nutrition. 2019;73:1283–1290eng
dc.identifier.issn0954-3007
dc.identifier.issn1476-5640
dc.identifier.urihttps://hdl.handle.net/1956/22766
dc.description.abstractBackground: There is growing evidence that nutritional interventions in the first 1000 days of life may influence long-term health and development outcomes. Few studies have examined the effect of maternal and infant micronutrient supplementation on development outcomes in sub-Saharan Africa. Methods: We conducted a follow-up study of two randomized trials of antenatal and infant micronutrient supplementation conducted in Dar es Salaam, Tanzania. We assessed the effect of maternal multiple micronutrient (MMN) supplementation in pregnancy on development of children at 11–14 years of age. We also examined the effect of infant zinc and MMN supplementation on development at 6–8 years of age. We used generalized linear models to assess standardized mean differences (SMDs) in general intelligence, executive function, and mental health scores. Results: We followed up 446 children whose mothers were enrolled in the maternal MMN supplementation trial and 365 children who were enrolled in the infant zinc and MMN supplementation trial. We found no effect of maternal MMN supplementation on general intelligence (SMD: −0.03; 95% CI: −0.15, 0.09), executive function (SMD: 0.00; 95% CI: −0.11, 0.11), and mental health scores (SMD: 0.06; 95% CI: 10.10, 0.22). We also found no effect of either infant zinc or MMN supplementation on any of the three development domains (p-values > 0.05). Conclusions: We found that antenatal MMN supplementation and infant zinc and MMN supplementation did not have a large effect on development outcomes in middle childhood and early adolescence in Tanzania.en_US
dc.language.isoengeng
dc.publisherNatureeng
dc.titleEffect of antenatal and infant micronutrient supplementation on middle childhood and early adolescent development outcomes in Tanzaniaeng
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2020-01-02T20:30:06Z
dc.description.versionacceptedVersion
dc.rights.holderCopyright 2019 The Author(s)eng
dc.identifier.doihttps://doi.org/10.1038/s41430-019-0403-3
dc.identifier.cristin1687618
dc.source.journalEuropean Journal of Clinical Nutrition


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