dc.contributor.author | Wyres, Kelly L. | en_US |
dc.contributor.author | Hawkey, Jane | en_US |
dc.contributor.author | Hetland, Marit | en_US |
dc.contributor.author | Fostervold, Aasmund | en_US |
dc.contributor.author | Wick, Ryan R. | en_US |
dc.contributor.author | Judd, Louise M. | en_US |
dc.contributor.author | Hamidian, Mohammad | en_US |
dc.contributor.author | Howden, Benjamin P. | en_US |
dc.contributor.author | Löhr, Iren Høyland | en_US |
dc.contributor.author | Holt, Kathryn E. | en_US |
dc.date.accessioned | 2020-07-02T07:55:23Z | |
dc.date.available | 2020-07-02T07:55:23Z | |
dc.date.issued | 2019 | |
dc.Published | Wyres, Hawkey, Hetland M, Fostervold A, Wick, Judd, Hamidian, Howden, Löhr IH, Holt KE. Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307. Journal of Antimicrobial Chemotherapy. 2019;74(3):577-581 | eng |
dc.identifier.issn | 0305-7453 | |
dc.identifier.issn | 1460-2091 | |
dc.identifier.uri | https://hdl.handle.net/1956/23223 | |
dc.description.abstract | Objectives: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. Methods: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). Results: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants. Conclusions: Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Oxford University Press | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.title | Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307 | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2020-01-30T13:11:53Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2018 The Authors | |
dc.identifier.doi | https://doi.org/10.1093/jac/dky492 | |
dc.identifier.cristin | 1703539 | |
dc.source.journal | Journal of Antimicrobial Chemotherapy | |