Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307
Wyres, Kelly L.; Hawkey, Jane; Hetland, Marit; Fostervold, Aasmund; Wick, Ryan R.; Judd, Louise M.; Hamidian, Mohammad; Howden, Benjamin P.; Löhr, Iren Høyland; Holt, Kathryn E.
Peer reviewed, Journal article
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Date
2019Metadata
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Original version
https://doi.org/10.1093/jac/dky492Abstract
Objectives: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. Methods: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). Results: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants. Conclusions: Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.