dc.contributor.author | Serkland, Trond T. | en_US |
dc.contributor.author | Schjøtt, Jan | en_US |
dc.contributor.author | Berg, Jon Andsnes | en_US |
dc.contributor.author | Herfindal, Lars | en_US |
dc.contributor.author | Riedel, Bettina | en_US |
dc.contributor.author | Skrede, Silje | en_US |
dc.date.accessioned | 2020-08-04T12:38:54Z | |
dc.date.available | 2020-08-04T12:38:54Z | |
dc.date.issued | 2019 | |
dc.Published | Serkland TT, Schjøtt JS, Berg JA, Herfindal L, Riedel B, Skrede S. Distribution of psychotropic drugs into lipoproteins. Therapeutic Drug Monitoring. 2019;41(6):766-771 | eng |
dc.identifier.issn | 1536-3694 | |
dc.identifier.issn | 0163-4356 | |
dc.identifier.uri | https://hdl.handle.net/1956/23409 | |
dc.description.abstract | Aim: The aim of this pilot study was to investigate whether psychotropic drugs frequently analyzed in a routine therapeutic drug monitoring laboratory bind to low-density lipoproteins/very-low-density lipoproteins (LDL/VLDL) in human serum. Methods: Drug concentrations in 20 serum sample pools containing one psychotropic drug each, and in the LDL/VLDL fractions extracted from the same samples, were measured by triple quadrupole liquid chromatography tandem mass spectrometry. The membrane permeability of the drugs was measured using a Parallel Artificial Membrane Permeability Assay. Results: Of the 20 antidepressants, antipsychotics, and antiepileptics examined, 7 drugs were detected in both the pooled serum samples and in the LDL/VLDL fraction. Binding of drugs to LDL/VLDL significantly correlated with high octanol: water partition coefficient (logP), high degree of protein binding, and a low polar surface area. The drugs found in LDL/VLDL, with the exception of aripiprazole, were also characterized by high or intermediate membrane permeability. Conclusions: The present results indicate that psychotropic drugs with certain characteristics bind to LDL/VLDL in blood. This further implies that lipoproteins could play an important role in drug transport. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Wolters Kluwer | eng |
dc.rights | Attribution-NonCommercial CC BY-NC | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | eng |
dc.title | Distribution of psychotropic drugs into lipoproteins | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2019-12-19T08:28:01Z | |
dc.description.version | acceptedVersion | en_US |
dc.rights.holder | Copyright 2019 Wolters Kluwer Health, Inc | |
dc.identifier.doi | https://doi.org/10.1097/ftd.0000000000000660 | |
dc.identifier.cristin | 1701792 | |
dc.source.journal | Therapeutic Drug Monitoring | |
dc.source.pagenumber | 766-771 | |
dc.identifier.citation | Therapeutic Drug Monitoring. 2019;41(6):766-771 | |
dc.source.volume | 41 | |
dc.source.issue | 6 | |