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dc.contributor.authorIrsheid, Linaen_US
dc.contributor.authorWehler, Thomasen_US
dc.contributor.authorBorek, Christophen_US
dc.contributor.authorKiefer, Werneren_US
dc.contributor.authorBrenk, Ruthen_US
dc.contributor.authorOrtiz-Soto, Maria Elenaen_US
dc.contributor.authorSeibel, Jurgenen_US
dc.contributor.authorSchirmeister, Tanjaen_US
dc.date.accessioned2020-08-07T12:38:12Z
dc.date.available2020-08-07T12:38:12Z
dc.date.issued2019-05-08
dc.PublishedIrsheid, Wehler T, Borek, Kiefer, Brenk R, Ortiz-Soto, Seibel, Schirmeister. Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design. PLOS ONE. 2019;14(5):e0216132eng
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1956/23570
dc.description.abstractGolgi α-mannosidase II (GMII) is a glycoside hydrolase playing a crucial role in the N-glycosylation pathway. In various tumour cell lines, the distribution of N-linked sugars on the cell surface is modified and correlates with the progression of tumour metastasis. GMII therefore is a possible molecular target for anticancer agents. Here, we describe the identification of a non-competitive GMII inhibitor using computer-aided drug design methods including identification of a possible allosteric binding site, pharmacophore search and virtual screening.en_US
dc.language.isoengeng
dc.publisherPLoSeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.titleIdentification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug designen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2019-11-15T11:44:23Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2019 The Authors
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0216132
dc.identifier.cristin1713716
dc.source.journalPLoS ONE


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