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Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control

dc.contributor.authorVarland, Sylviaen_US
dc.contributor.authorVandekerckhove, Joelen_US
dc.contributor.authorDrazic, Adrianen_US
dc.date.accessioned2020-08-13T13:23:43Z
dc.date.available2020-08-13T13:23:43Z
dc.date.issued2019
dc.PublishedVarland S, Vandekerckhove J, Drazic A. Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control. TIBS -Trends in Biochemical Sciences. 2019:44(6):502-516eng
dc.identifier.issn1362-4326
dc.identifier.issn0968-0004
dc.identifier.urihttps://hdl.handle.net/1956/23753
dc.description.abstractActin is one of the most abundant proteins in eukaryotic cells and the main component of the microfilament system. It plays essential roles in numerous cellular activities including muscle contraction, maintenance of cell integrity and motility, as well as transcriptional regulation. Besides interacting with various actin-binding proteins (ABPs), proper actin function is regulated by posttranslational modifications (PTMs), such as acetylation, arginylation, oxidation, and others. Here, we explain how actin PTMs can contribute to filament formation and stability, and may have additional actin regulatory functions, which potentially contribute to disease development.en_US
dc.language.isoengeng
dc.publisherElseviereng
dc.relation.urihttps://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(18)30259-7
dc.rightsAttribution-Non Commercial-No Derivatives CC BY-NC-NDeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/eng
dc.titleActin Post-translational Modifications: The Cinderella of Cytoskeletal Controlen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2019-11-27T12:08:09Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2019 The Authors
dc.identifier.doihttps://doi.org/10.1016/j.tibs.2018.11.010
dc.identifier.cristin1635945
dc.source.journalTIBS -Trends in Biochemical Sciences. Regular ed.
dc.relation.projectEC/FP7: 608695
dc.relation.projectNorges forskningsråd: 261981
dc.relation.projectNorges forskningsråd: 249843


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