Show simple item record

dc.contributor.authorMadsen, Liseen_US
dc.contributor.authorPedersen, Lone M.en_US
dc.contributor.authorLillefosse, Haldis Haukaasen_US
dc.contributor.authorFjære, Evenen_US
dc.contributor.authorBrønstad, Ingeborgen_US
dc.contributor.authorHao, Qinen_US
dc.contributor.authorPetersen, Rasmus Koefoeden_US
dc.contributor.authorHallenborg, Philipen_US
dc.contributor.authorMa, Taoen_US
dc.contributor.authorDe Matteis, Ritaen_US
dc.contributor.authorAraujo, Pedroen_US
dc.contributor.authorMercader, Josepen_US
dc.contributor.authorBonet, M. Luisaen_US
dc.contributor.authorHansen, Jacob B.en_US
dc.contributor.authorCannon, Barbaraen_US
dc.contributor.authorNedergaard, Janen_US
dc.contributor.authorWang, Junen_US
dc.contributor.authorCinti, Saverioen_US
dc.contributor.authorVoshol, Peteren_US
dc.contributor.authorDøskeland, Stein Oveen_US
dc.contributor.authorKristiansen, Karstenen_US
dc.PublishedPLoS ONE 5(6): e11391en
dc.description.abstractBackground The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. Methodology/Principal Findings Here we report that cyclooxygenase (COX) activity and prostaglandin E2 (PGE2) are crucially involved in induction of UCP1 expression in inguinal white adipocytes, but not in classic interscapular brown adipocytes. Cold-induced expression of UCP1 in inguinal white adipocytes was repressed in COX2 knockout (KO) mice and by administration of the COX inhibitor indomethacin in wild-type mice. Indomethacin repressed β-adrenergic induction of UCP1 expression in primary inguinal adipocytes. The use of PGE2 receptor antagonists implicated EP4 as a main PGE2 receptor, and injection of the stable PGE2 analog (EP3/4 agonist) 16,16 dm PGE2 induced UCP1 expression in inguinal white adipose tissue. Inhibition of COX activity attenuated diet-induced UCP1 expression and increased energy efficiency and adipose tissue mass in obesity-resistant mice kept at thermoneutrality. Conclusions/Significance Our findings provide evidence that induction of UCP1 expression in white adipose tissue, but not in classic interscapular brown adipose tissue is dependent on cyclooxygenase activity. Our results indicate that cyclooxygenase-dependent induction of UCP1 expression in white adipose tissues is important for diet-induced thermogenesis providing support for a surprising role of COX activity in the control of energy balance and obesity development.en_US
dc.publisherPublic Library of Scienceeng
dc.rightsAttribution CC BYeng
dc.titleUCP1 induction during recruitment of Brown Adipocytes in White Adipose tissue is dependent on Cyclooxygenase activityen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2010 Madsen et al.
dc.rights.holderMadsen et al.
dc.subject.nsiVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726nob

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY