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dc.contributor.authorAkaddar, Azizaen_US
dc.contributor.authorDoderer-Lang, Cécileen_US
dc.contributor.authorMarzahn, Melissa R.en_US
dc.contributor.authorDelalande, Françoisen_US
dc.contributor.authorMousli, Marcen_US
dc.contributor.authorHelle, Karen Blaauwen_US
dc.contributor.authorDorsselaer, Alainen_US
dc.contributor.authorAunis, Dominiqueen_US
dc.contributor.authorDunn, Ben M.en_US
dc.contributor.authorMetz-Boutigue, Marie-Hélèneen_US
dc.contributor.authorCandolfi, Ermannoen_US
dc.PublishedCellular and Molecular Life Sciences 67: 1005-1015en_US
dc.description.abstractCatestatin, an endogenous peptide derived from bovine chromogranin A, and its active domain cateslytin display powerful antimicrobial activities. We have tested the activities of catestatin and other related peptides on the growth of Plasmodium falciparum in vitro. Catestatin inhibits growth of the chloroquine-sensitive strain of P. falciparum 3D7, exhibiting 88% inhibition at 20 lM. A similar partial inhibition of parasite growth was observed for the chloroquine-resistant strain, 7G8 (64%,) and the multidrug-resistant strain, W2 (62%). In the presence of parasite-specific lactate dehydrogenase, a specific protein– protein interaction between catestatin and plasmepsin II precursor was demonstrated. In addition, catestatin partially inhibited the parasite-specific proteases plasmepsin in vitro. A specific interaction between catestatin and plasmepsins II and IV from P. falciparum and plasmepsin IV from the three remaining species of Plasmodium known to infect man was observed, suggesting a catestatininduced reduction in availability of nutrients for protein synthesis in the parasite.en_US
dc.rightsAttribution-NonCommercial CC BY-NCeng
dc.subjectPlasmodium falciparumeng
dc.subjectAntimicrobial peptideeng
dc.subjectChromogranin Aeng
dc.subjectPlasmepsins II and IVeng
dc.titleCatestatin, an endogenous Chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparumen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s) 2009. This article is published with open access at
dc.rights.holderThe Author(s) 2009
dc.subject.nsiVDP::Medical disciplines: 700eng

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