dc.contributor.author | Andersen, Aase B. | en_US |
dc.contributor.author | Range, Nyagosya S. | en_US |
dc.contributor.author | Changalucha, John | en_US |
dc.contributor.author | PrayGod, George | en_US |
dc.contributor.author | Kidola, Jeremiah | en_US |
dc.contributor.author | Grewal, Harleen M. S. | en_US |
dc.contributor.author | Faurholt-Jepsen, Daniel | en_US |
dc.contributor.author | Krarup, Henrik | en_US |
dc.contributor.author | Friis, Henrik | en_US |
dc.date.accessioned | 2013-05-27T10:04:21Z | |
dc.date.available | 2013-05-27T10:04:21Z | |
dc.date.issued | 2012-03-21 | eng |
dc.Published | BMC Infectious Diseases 2012, 12:66 | eng |
dc.identifier.issn | 1471-2334 | |
dc.identifier.uri | https://hdl.handle.net/1956/6661 | |
dc.description.abstract | Background: The interaction of HIV and tuberculosis (TB) on CD4 levels over time is complex and has been divergently reported. Methods: CD4 counts were assessed from time of diagnosis till the end of TB treatment in a cohort of pulmonary TB patients with and without HIV co-infection and compared with cross-sectional data on age- and sex-matched non-TB controls from the same area. Results: Of 1,605 study participants, 1,250 were PTB patients and 355 were non-TB controls. At baseline, HIV was associated with 246 (95% CI: 203; 279) cells per μL lower CD4 counts. All PTB patients had 100 cells per μL lower CD4 counts than the healthy controls. The CD4 levels were largely unchanged during a five-month of TB treatment. HIV infected patients not receiving ART at any time and those already on ART at baseline had no increase in CD4 counts after 5 months of TB treatment, whereas those prescribed ART between baseline and 2 months, and between 2 and 5 months increased by 69 (22;117) and 110 (52; 168) CD4 cells per μL after 5 months. Conclusions: The increase in circulating CD4 levels observed in PTB in patients is acquired after 2 months of treatment irrespective of HIV status. Initiation of ART is the strongest factor correlated with CD4 increase during TB treatment. | en_US |
dc.language.iso | eng | eng |
dc.publisher | BioMed Central | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | eng |
dc.subject | Pulmonary tuberculosis | eng |
dc.subject | HIV | eng |
dc.subject | CD4 cells | eng |
dc.subject | TB treatment | eng |
dc.title | CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without hiv co-infection | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2012 Andersen et al; licensee BioMed Central Ltd. | |
dc.identifier.doi | https://doi.org/10.1186/1471-2334-12-66 | |
dc.identifier.cristin | 944834 | |
dc.source.journal | BMC Infectious Diseases | |
dc.source.40 | 12 | |