Blar i Department of Clinical Science på tidsskrift "PLoS ONE"
Viser treff 21-40 av 52
-
Genetic diversity of circulating rotavirus strains in Tanzania prior to the introduction of vaccination
(Peer reviewed; Journal article, 2014-05-20)Background: Tanzania currently rolls out vaccination against rotavirus-diarrhea, a major cause of child illness and death. As the vaccine covers a limited number of rotavirus variants, this study describes the molecular ... -
The HDACi panobinostat shows growth inhibition both in vitro and in a bioluminescent orthotopic surgical xenograft model of ovarian cancer
(Peer reviewed; Journal article, 2016-06-28)Background: In most epithelial ovarian carcinomas (EOC), epigenetic changes are evident, and overexpression of histone deacetylases (HDACs) represents an important manifestation. In this study, we wanted to evaluate the ... -
High prevalence of faecal carriage of ESBL-producing enterobacteriaceae among children in Dar es Salaam, Tanzania
(Peer reviewed; Journal article, 2016-12-09)Background: Faecal carriage of ESBL-producing bacteria is a potential risk for transmission and infection. Little is known about faecal carriage of antibiotic resistance in Tanzania. This study aimed to investigate the ... -
Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial
(Peer reviewed; Journal article, 2017-05-02)Pathologically elevated immune activation and inflammation contribute to HIV disease progression and immunodeficiency, potentially mediated by elevated levels of prostaglandin E2, which suppress HIV-specific T cell responses. ... -
Increased severity and mortality in adults co-infected with malaria and HIV in Maputo, Mozambique: a prospective cross-sectional study
(Peer reviewed; Journal article, 2014-02-05)Background: Co-infection with falciparum malaria and HIV-1 increases the severity and mortality of both infections in unstable malaria-transmission areas. In contrast, in stable transmission areas, HIV co-infection increases ... -
Inflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgery
(Peer reviewed; Journal article, 2018-02-05)Objective: Obesity is associated with increased inflammation and insulin resistance. In conditions with chronic immune activation, low plasma vitamin B6-levels are described, as well as an increased kynurenine:tryptophan-ratio ... -
Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge
(Peer reviewed; Journal article, 2014-05-21)We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret ... -
Investigation of complement component C4 copy number variation in human longevity
(Peer reviewed; Journal article, 2014-01-22)Genetic factors have been estimated to account for about 25% of the variation in an adult’s life span. The complement component C4 with the isotypes C4A and C4B is an effector protein of the immune system, and differences ... -
Is atopic sensitization associated with indicators of early vascular ageing in adolescents?
(Peer reviewed; Journal article, 2019)Background: Chronic systemic inflammation accelerates early vascular ageing. Atopic sensitization and allergic diseases may involve increased inflammatory activity. This study aimed to assess whether atopic sensitization ... -
Late-week surgical treatment of endometrial cancer is associated with worse long-term outcome: Results from a prospective, multicenter study
(Peer reviewed; Journal article, 2017-08-03)Surgery is the cornerstone in primary endometrial cancer treatment, and with curative intent it constitutes total hysterectomy and bilateral salpingo-oopherectomy. In addition, lymphadenectomy is performed in selected ... -
The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease
(Journal article; Peer reviewed, 2022)Background The lower airways microbiome and host immune response in chronic pulmonary diseases are incompletely understood. We aimed to investigate possible microbiome characteristics and key antimicrobial peptides and ... -
A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats
(Peer reviewed; Journal article, 2019-09-24)A fatty acid analogue, 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), was previously shown to have hypolipidemic effects in rats by targeting mitochondrial activity predominantly in liver. This study aimed to determine ... -
Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma
(Peer reviewed; Journal article, 2015-08-07)Background: Orthotopic endometrial cancer models provide a unique tool for studies of tumour growth and metastatic spread. Novel preclinical imaging methods also have the potential to quantify functional tumour characteristics ... -
A novel fibrosis index comprising a non-cholesterol sterol accurately predicts HCV-related liver cirrhosis
(Peer reviewed; Journal article, 2014-04-03)Diagnosis of liver cirrhosis is essential in the management of chronic hepatitis C virus (HCV) infection. Liver biopsy is invasive and thus entails a risk of complications as well as a potential risk of sampling error. ... -
Parent psychological wellbeing in a single-family room versus an open bay neonatal intensive care unit
(Peer reviewed; Journal article, 2019-11-05)Background Studies of parents’ psychological well-being in single-family rooms in neonatal intensive care units have shown conflicting results. Aims To compare emotional distress in the form of depression, anxiety, stress ... -
Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study
(Peer reviewed; Journal article, 2017-07-10)Background Delirium is common in hip fracture patients and many risk factors have been identified. Controversy exists regarding the possible impact of intraoperative control of blood pressure upon acute (delirium) and long ... -
Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer
(Peer reviewed; Journal article, 2019)Objective: Better biomarkers are needed in order to identify patients with endometrial carcinoma at risk of recurrence and who may profit from a more aggressive treatment regimen. Our objective was to explore the applicability ... -
A positive association between nutritional risk and the incidence of surgical site infections: A hospital-based register study
(Peer reviewed; Journal article, 2018-05-15)Surgical site infections (SSI) are amongst the most common health care-associated infections and have adverse effects for patient health and for hospital resources. Although surgery guidelines recognize poor nutritional ... -
Predicting preeclampsia from a history of preterm birth
(Peer reviewed; Journal article, 2017-07-24)Objective: To assess whether women with a history of preterm birth, independent on the presence of prelabour rupture of the membranes (PROM) and growth deviation of the newborn, are more likely to develop preeclampsia with ... -
Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study
(Peer reviewed; Journal article, 2014-10-03)Background: COPD exacerbations accelerate disease progression. Aims To examine if COPD characteristics and systemic inflammatory markers predict the risk for acute COPD exacerbation (AECOPD) frequency and duration. Methods: ...