Browsing Department of Clinical Science by Journals "Journal of Experimental Medicine (JEM)"
Now showing items 1-2 of 2
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Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1
(Journal article; Peer reviewed, 2021)Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing ... -
Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency
(Journal article; Peer reviewed, 2022)Autosomal recessive IRF7 deficiency was previously reported in three patients with single critical influenza or COVID-19 pneumonia episodes. The patients’ fibroblasts and plasmacytoid dendritic cells produced no detectable ...