Blar i Department of Clinical Science på emneord "Schizophrenia"
Viser treff 1-7 av 7
-
Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
(Peer reviewed; Journal article, 2018-12-11)Introduction: The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of modern ... -
Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders
(Peer reviewed; Journal article, 2019-03-08)Objective: Associations between suicidality and lipid dysregulation are documented in mental illness, but the potential role of leptin remains unclear. We examined the association between leptin and suicidal behaviour in ... -
Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders.
(Peer reviewed; Journal article, 2018-05-02)Although the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. ... -
Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders
(Peer reviewed; Journal article, 2017-06-09)The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is ... -
Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients
(Peer reviewed; Journal article, 2019-04-27)To investigate whether changes in serum lipids are associated with cognitive performance in first episode psychosis (FEP) patients during their first year of antipsychotic drug treatment. One hundred and thirty-two ... -
Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis
(Peer reviewed; Journal article, 2017-07)Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug ... -
Recently evolved human-specific methylated regions are enriched in schizophrenia signals
(Peer reviewed; Journal article, 2018)Background: One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution. This hypothesis is supported by evidence suggesting that ...