• Effects of anthocyanin supplementation on serum lipids, glucose, markers of inflammation and cognition in adults with increased risk of dementia - A pilot study 

      Bergland, Anne Katrine; Sønnesyn, Hogne; Dalen, Ingvild; Rodriguez-Mateos, Ana; Berge, Rolf Kristian; Melvær, Giil Lasse; Rajendran, Lawrence; Siow, Richard; Tassotti, Michele; Larsen, Alf Inge; Aarsland, Dag (Peer reviewed; Journal article, 2019-06-11)
      Background: Anthocyanins may protect against cardiovascular related cognitive decline and dementia. Objective: Open-label study to measure changes in serum lipids, glucose, glycosylated hemoglobin (HbA1c), and markers of ...
    • Effects of purified anthocyanins in people at risk for dementia: Study protocol for a phase II randomized controlled trial 

      Khalifa, Khadija; Bergland, Anne Katrine; Sønnesyn, Hogne; Oppedal, Ketil; Oesterhus, Ragnhild; Dalen, Ingvild; Larsen, Alf Inge; Fladby, Tormod; Brooker, Helen; Wesnes, Keith A.; Ballard, Clive; Aarsland, Dag (Journal article; Peer reviewed, 2020)
      Background: The number of people with dementia is increasing, with huge challenges for society and health-care systems. There are no disease-modifying therapies available. There is, therefore, an urgent need to identify ...
    • High prevalence of orthostatic hypotension in mild dementia 

      Sønnesyn, Hogne; Nilsen, Dennis W. T.; Rongve, Arvid; Nore, Sabine; Ballard, Clive; Tysnes, Ole-Bjørn; Aarsland, Dag (Peer reviewed; Journal article, 2009-11)
      Background/Aims: Orthostatic hypotension (OH) and QTc prolongation have potentially important prognostic and therapeutic consequences but have rarely been studied in patients with mild dementia. Methods: Patients with mild ...
    • Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia 

      Solvang, Stein-Erik Hafstad; Nordrehaug, Jan Erik; Aarsland, Dag; Lange, Johannes; Ueland, Per Magne; McCann, Adrian; Midttun, Øivind; Tell, Grethe S.; Melvær, Giil Lasse (Journal article; Peer reviewed, 2019)
      Introduction: Circulating tryptophan (Trp) and its downstream metabolites, the kynurenines, are potentially neuroactive. Consequently, they could be associated with neuropsychiatric symptoms and cognitive prognosis in ...
    • Persistence and Prognostic Implications of Orthostatic Hypotension in Older Individuals with Mild-to-Moderate Dementia 

      Sønnesyn, Hogne; Dalen, Ingvild; Aarsland, Dag (Peer reviewed; Journal article, 2014)
      Aim: To study the course and prognostic implications of orthostatic hypotension (OH) in older individuals with mild-to-moderate dementia. Methods: Referrals to outpatient clinics specialising in old age psychiatry and ...
    • Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease 

      Desikan, Rahul S.; Schork, Andrew J.; Wang, Yunpeng; Thompson, Wesley K.; Dehghan, Abbas; Ridker, Paul M.; Chasman, Daniel I.; McEvoy, Linda K.; Holland, Dominic; Chen, Chi-Hua; Karow, David S.; Brewer, James B.; Hess, Christopher P.; Williams, Julie; Sims, Rebecca; O'Donovan, Michael C.; Choi, Seung Hoan; Bis, Joshua C.; Ikram, M. Arfan; Gudnason, Vilmundur; DeStefano, Anita L.; Van Der Lee, Sven J.; Psaty, Bruce M.; Van Duijn, Cornelia M.; Launer, Lenore; Seshadri, Sudha; Pericak-Vance, Margaret A.; Mayeux, Richard; Haines, Jonathan L.; Farrer, Lindsay A.; Hardy, John; Ulstein, Ingun; Aarsland, Dag; Fladby, Tormod; White, Linda; Sando, Sigrid Botne; Rongve, Arvid; Witoelar, Aree; Djurovic, Srdjan; Hyman, Bradley T.; Snædal, Jon; Steinberg, Stacy; Stefansson, Hreinn; Stefánsson, Kári; Schellenberg, Gerard D.; Andreassen, Ole Andreas; Dale, Anders (Peer reviewed; Journal article, 2015-06)
      Background—Epidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. We investigated whether this ...
    • Relationship between Orthostatic Hypotension and White Matter Hyperintensity Load in Older Patients with Mild Dementia 

      Sønnesyn, Hogne; Nilsen, Dennis W. T.; Oppedal, Ketil; Greve, Ole Jacob; Beyer, Mona K.; Aarsland, Dag (Peer reviewed; Journal article, 2012-12-19)
      Background/Objectives: White matter hyperintensities (WMH) in magnetic resonance imaging (MRI) scans of the brain, and orthostatic hypotension (OH) are both common in older people. We tested the hypothesis that OH is ...
    • White Matter Hyperintensities and the Course of Depressive Symptoms in Elderly People with Mild Dementia 

      Sønnesyn, Hogne; Oppedal, Ketil; Greve, Ole Jacob; Fritze, Friederike; Auestad, Bjørn Henrik; Nore, Sabine; Beyer, Mona K.; Aarsland, Dag (Peer reviewed; Journal article, 2012)
      Objectives: To explore the relationship between white matter hyperintensities (WMH) and the prevalence and course of depressive symptoms in mild Alzheimer’s disease (AD) and Lewy body dementia. Design: This is a prospective ...