• Airway obstruction, dynamic hyperinflation, and breathing pattern during incremental exercise in COPD patients 

      Frisk, Bente; Espehaug, Birgitte; Hardie, Jon Andrew; Strand, Liv Inger; Moe-Nilssen, Rolf; Eagan, Tomas Mikal; Bakke, Per; Thorsen, Einar (Peer reviewed; Journal article, 2014-02-01)
      Ventilatory capacity is reduced in chronic obstructive pulmonary disease (COPD) patients. Tidal volume (VT) is lower and breathing frequency higher at a given ventilation (VE) compared to healthy subjects. We examined ...
    • The association of tidal EFL with exercise performance, exacerbations, and death in COPD 

      Aarli, Bernt Bøgvald; Calverley, Peter M.A.; Jensen, Robert L.; Dellacà, Raffaele; Eagan, Tomas Mikal; Bakke, Per S.; Hardie, Jon Andrew (Peer reviewed; Journal article, 2017-07-26)
      Background: Tidal expiratory flow limitation (EFLT) is frequently found in patients with COPD and can be detected by forced oscillations when within-breath reactance of a single-breath is ≥0.28 kPa·s·L-1. The present study ...
    • Change in pulmonary diffusion capacity in a general population sample over 9 years 

      Storebø, Michael Langballe; Eagan, Tomas Mikal; Eide, Geir Egil; Gulsvik, Amund; Thorsen, Einar; Bakke, Per S. (Peer reviewed; Journal article, 2016-09-02)
      Rationale: Data on the change in diffusion capacity of the lung for carbon monoxide (DLCO) over time are limited. We aimed to examine change in DLCO (ΔDLCO) over a 9-year period and its predictors. Methods: A Norwegian ...
    • Change in pulmonary diffusion capacity in a general population sample over 9 years 

      Storebø, Michael Langballe; Eagan, Tomas Mikal; Eide, Geir Egil; Gulsvik, Amund; Thorsen, Einar; Bakke, Per S. (Peer reviewed; Journal article, 2016-09-02)
      Rationale: Data on the change in diffusion capacity of the lung for carbon monoxide (DL_CO) over time are limited. We aimed to examine change in DL_CO (ΔDL_CO) over a 9-year period and its predictors. Methods: A Norwegian ...
    • Chronic Obstructive Pulmonary Disease Is Associated with Low Levels of Vitamin D 

      Persson, Louise Jeanette Pauline; Aanerud, Marianne; Hiemstra, Pieter Sicco; Hardie, Jon Andrew; Bakke, Per; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2012-06-21)
      Introduction: COPD patients may be at increased risk for vitamin D (25(OH)D) deficiency, but risk factors for deficiency among COPD patients have not been extensively reported. Methods: Serum 25(OH)D levels were measured ...
    • Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients 

      Tangedal, Solveig; Aanerud, Marianne; Grønseth, Rune; Drengenes, Christine; Wiker, Harald G; Bakke, Per S.; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2017-08-29)
      Background: Induced and spontaneous sputum are used to evaluate the airways microbiota. Whether the sputum types can be used interchangeably in microbiota research is unknown. Our aim was to compare microbiota in induced ...
    • Comparison of inflammatory markers in induced and spontaneous sputum in a cohort of COPD patients 

      Tangedal, Solveig; Aanerud, Marianne; Persson, Louise Jeanette Pauline; Brokstad, Karl Albert; Bakke, Per S.; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2014-11-15)
      Background: Sputum induction is a non-invasive method for obtaining measurements of inflammation in the airways. Whether spontaneously sampled sputum can be a valid surrogate is unknown. The aim of this study was to compare ...
    • Complications and discomfort of bronchoscopy: a systematic review 

      Leiten, Elise Orvedal; Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal; Bakke, Per S.; Grønseth, Rune (Peer reviewed; Journal article, 2016)
      Objective: To identify bronchoscopy-related complications and discomfort, meaningful complication rates, and predictors. Method: We conducted a systematic literature search in PubMed on 8 February 2016, using a search ...
    • Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls 

      van der Does, Anne M; Heijink, Marieke; Mayboroda, Oleg A.; Persson, Louise Jeanette Pauline; Aanerud, Marianne; Bakke, Per S.; Eagan, Tomas Mikal; Hiemstra, Pieter S.; Giera, Martin (Peer reviewed; Journal article, 2019)
      Introduction: Disturbances in onset and resolution of inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. Dietary polyunsaturated fatty acids (PUFAs) can be converted into lipid mediators ...
    • Exploring protocol bias in airway microbiome studies: one versus two PCR steps and 16S rRNA gene region V3 V4 versus V4 

      Drengenes, Christine; Eagan, Tomas Mikal; Haaland, Ingvild; Wiker, Harald G; Nielsen, Rune (Journal article; Peer reviewed, 2021)
      Background Studies on the airway microbiome have been performed using a wide range of laboratory protocols for high-throughput sequencing of the bacterial 16S ribosomal RNA (16S rRNA) gene. We sought to determine the ...
    • ILD-­specific health-­related quality of life in systemic sclerosis-­associated ILD compared with IPF 

      Durheim, Michael; Hoffmann-Vold, Anna-Maria; Eagan, Tomas Mikal; Hovden, Arnt-Ove; Samersaw-Lund, May Brit; Bjerke, Gisle; Birring, Surinder S.; Jonassen, Trygve Müller; Johansen, Odd Erik; Sjåheim, Tone Bjørg (Journal article; Peer reviewed, 2020)
      Abstract Introduction Idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) are fibrotic ILDs with divergent disease populations. Little is known about health-related ...
    • Incidence of utilization- and symptom-defined COPD exacerbations in hospital- and population-recruited patients 

      Erdal, Marta; Johannessen, Ane; Eagan, Tomas Mikal; Bakke, Per S.; Gulsvik, Amund; Grønseth, Rune (Peer reviewed; Journal article, 2016-09)
      Objectives: The objectives of this study were to estimate the impact of recruitment source and outcome definition on the incidence of acute exacerbations of COPD (AECOPD) and explore possible predictors of AECOPD. Patients ...
    • Incremental costs of COPD exacerbations in GOLD stage 2+ COPD in ever-smokers of a general population 

      Erdal, Marta; Johannessen, Ane; Bakke, Per S.; Gulsvik, Amund; Eagan, Tomas Mikal; Nielsen, Rune (Journal article; Peer reviewed, 2020-11)
      Objectives To estimate treatment- and productivity-related costs associated with COPD in two different samples, and to analyse the association between the costs and moderate and severe exacerbations. Methods We performed ...
    • Laboratory contamination in airway microbiome studies 

      Drengenes, Christine; Wiker, Harald G; Kalananthan, Tharmini; Nordeide, Eli; Eagan, Tomas Mikal; Nielsen, Rune (Peer reviewed; Journal article, 2019-08-14)
      Background The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from bacterial DNA introduced during sampling and laboratory processing. We have ...
    • Lung hyperinflation and functional exercise capacity in patients with COPD - a three-year longitudinal study 

      Aalstad, Linn T.; Hardie, Jon Andrew; Espehaug, Birgitte; Thorsen, Einar; Bakke, Per S.; Eagan, Tomas Mikal; Frisk, Bente (Peer reviewed; Journal article, 2018-12-06)
      Background: Lung hyperinflation contributes to dyspnea, morbidity and mortality in chronic obstructive pulmonary disease (COPD). The inspiratory-to-total lung capacity (IC/TLC) ratio is a measure of lung hyperinflation and ...
    • Motivation and response rates in bronchoscopy studies 

      Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal; Leiten, Elise Orvedal; Nordeide, Eli; Bakke, Per S.; Lehmann, Sverre; Nielsen, Rune (Peer reviewed; Journal article, 2019-05-02)
      Background Bronchoscopy is frequently used to sample the lower airways in lung microbiome studies. Despite being a safe procedure, it is associated with discomfort that may result in reservations regarding participation ...
    • Participation in research bronchoscopy: a literature review 

      Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Bakke, Per S.; Eagan, Tomas Mikal; Grønseth, Rune (Peer reviewed; Journal article, 2016-02-03)
      Bronchoscopy is the preferred method for collecting biological samples from the lower airways of subjects in clinical research. However, ensuring participation in clinical research can be challenging when the research ...
    • Peak oxygen uptake and breathing pattern in COPD patients – a four-year longitudinal study 

      Frisk, Bente; Hardie, Jon Andrew; Espehaug, Birgitte; Strand, Liv Inger; Moe-Nilssen, Rolf; Eagan, Tomas Mikal; Bakke, Per; Thorsen, Einar (Peer reviewed; Journal article, 2015-08-19)
      Background: Activities of daily living in patients with chronic obstructive pulmonary disease (COPD) are limited by exertional dyspnea and reduced exercise capacity. The aims of the study were to examine longitudinal changes ...
    • Predictors of diagnostic yield in bronchoscopy: a retrospective cohort study comparing different combinations of sampling techniques 

      Roth, Kjetil; Hardie, Jon Andrew; Andreassen, Alf H.; Leh, Friedemann; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2008-01-26)
      Background: The reported diagnostic yield from bronchoscopies in patients with lung cancer varies greatly. The optimal combination of sampling techniques has not been finally established. The objectives of this study were ...
    • Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study 

      Husebø, Gunnar Reksten; Bakke, Per; Aanerud, Marianne; Hardie, Jon Andrew; Ueland, Thor; Grønseth, Rune; Persson, Louise Jeanette Pauline; Aukrust, Pål; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2014-10-03)
      Background: COPD exacerbations accelerate disease progression. Aims To examine if COPD characteristics and systemic inflammatory markers predict the risk for acute COPD exacerbation (AECOPD) frequency and duration. Methods: ...