Browsing Department of Clinical Science by Author "Wahren Herlenius, Marie Elisabeth"

Now showing items 1-7 of 7

    • Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider 

      Rodríguez-Carrio, Javier; Burska, Agata; Conaghan, P.G.; Dik, Willem A; Biesen, Robert; Eloranta, Maija-Leena; Cavalli, Giulio; Visser, Marianne; Boumpas, Dimitrios T; Bertsias, George; Wahren Herlenius, Marie Elisabeth; Rehwinkel, Jan; Frémond, Marie-Louise; Crow, Mary K; Ronnblom, Lars; Vital, Ed; Versnel, Marjan (Journal article; Peer reviewed, 2023)
      Background: Type I interferons (IFN-I) contribute to a broad range of rheumatic and musculoskeletal diseases (RMDs). Compelling evidence suggests that the measurement of IFN-I pathway activation may have clinical value. ...

    • Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies 

      Preger, Charlotta; Notarnicola, Antonella; Hellström, Cecilia; Wigren, Edvard; Fernandes-Cerqueira, Cátia; Kvarnström, Marika; Wahren Herlenius, Marie Elisabeth; Idborg, Helena; Lundberg, Ingrid E.; Persson, Helena; Gräslund, Susanne; Jakobsson, Per-Johan (Journal article; Peer reviewed, 2023)
      Objectives: Autoantibodies are thought to play a key role in the pathogenesis of idiopathic inflammatory myopathies (IIM). However, up to 40% of IIM patients, even those with clinical manifestations of anti-synthetase ...

    • Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases 

      Lundtoft, Christian; Pucholt, Pascal; Martin, Myriam; Bianchi, Matteo; Lundström, Emeli; Eloranta, Maija-Leena; Sandling, Johanna K.; Sjöwall, Christopher; Jönsen, Andreas; Gunnarsson, Iva; Rantapää-Dahlqvist, Solbritt; Bengtsson, Anders A.; Leonard, Dag; Baecklund, Eva; Jonsson, Roland; Hammenfors, Daniel; Forsblad-d'Elia, Helena; Eriksson, Per; Mandl, Thomas; Magnusson Bucher, Sara; Norheim, Katrine Brække; Johnsen, Svein Joar Auglæn; Omdal, Roald; Kvarnström, Marika; Wahren Herlenius, Marie Elisabeth; Notarnicola, Antonella; Andersson, Anna Helena; Molberg, Øyvind; Diederichsen, Louise Pyndt; Almlöf, Jonas; Syvänen, Ann-Christine; Kozyrev, Sergey V.; Lindblad-Toh, Kerstin; Rönnblom, Lars; Brokstad, Karl Albert; Skarstein, Kathrine; Jonsson, Malin Viktoria; Appel, Silke; Aqrawi, Lara A.; Jensen, Janicke Liaaen; Palm, Øyvind; Nilsson, Birgitta Blakstad; Blom, Anna M.; Lundberg, Ingrid E.; Nordmark, Gunnel; Diaz-Gallo, Lina Marcela; Svenungsson, Elisabet; Rönnblom, Lars (Journal article; Peer reviewed, 2022)
      Objective Copy number variation of the C4 complement components, C4A and C4B, has been associated with systemic inflammatory autoimmune diseases. This study was undertaken to investigate whether C4 copy number variation ...

    • Skin infiltrating NK cells in cutaneous T-cell lymphoma are increased in number and display phenotypic alterations partially driven by the tumor 

      Scheffschick, Andrea; Nenonen, Julia; Xiang, Mengmeng; Winther, Anna H.; Ehrström, Marcus; Wahren Herlenius, Marie Elisabeth; Eidsmo, Liv; Brauner, Hanna (Journal article; Peer reviewed, 2023)
      Cutaneous T-cell lymphomas (CTCL) are characterized by focal infiltration of malignant T cell clones in solitary skin lesions. Many CTCL patients experience an indolent disease, but some progress to advanced disease with ...

    • SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development 

      Gao, Yu; Liu, Ruining; He, Chenfei; Basile, Juan; Vesterlund, Mattias; Wahren Herlenius, Marie Elisabeth; Espinoza, Alexander; Hokka-Zakrisson, Cassandra; Zadjali, Fahad; Yoshimura, Akihiko; Karlsson, Mikael; Carow, Berit; Rottenberg, Martin E. (Journal article; Peer reviewed, 2021)
      The suppressor of cytokine signaling 3 (SOCS3) is a major regulator of immune responses and inflammation as it negatively regulates cytokine signaling. Here, the role of SOCS3 in thymic T cell formation was studied in ...

    • Strong association of combined genetic deficiencies in the classical complement pathway with risk of systemic lupus erythematosus and primary Sjögren's syndrome 

      Lundtoft, Christian; Sjöwall, Christopher; Rantapää-Dahlqvist, Solbritt; Bengtsson, Anders A.; Jönsen, Andreas; Pucholt, Pascal; Wu, Yee Ling; Lundström, Emeli; Eloranta, Maija-Leena; Gunnarsson, Iva; Baecklund, Eva; Jonsson, Roland; Hammenfors, Daniel; Forsblad-d'Elia, Helena; Eriksson, Per; Mandl, Thomas; Bucher, Sara; Norheim, Katrine Brække; Johnsen, Svein Joar Auglæn; Omdal, Roald; Kvarnström, Marika; Wahren Herlenius, Marie Elisabeth; Truedsson, Lennart; Nilsson, Bo; Kozyrev, Sergey V.; Bianchi, Matteo; Lindblad-Toh, Kerstin; Yu, Chack-Yung; Nordmark, Gunnel; Sandling, Johanna K.; Svenungsson, Elisabet; Leonard, Dag; Rönnblom, Lars (Journal article; Peer reviewed, 2022)
      Objective Complete genetic deficiency of the complement component C2 is a strong risk factor for monogenic systemic lupus erythematosus (SLE), but whether heterozygous C2 deficiency adds to the risk of SLE or primary ...

    • Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider 

      Burska, Agata; Rodríguez-Carrio, Javier; Biesen, Robert; Dik, Willem A.; Eloranta, Maija-Leena; Cavalli, Giulio; Visser, Marianne; Boumpas, Dimitrios T.; Bertsias, George; Wahren Herlenius, Marie Elisabeth; Rehwinkel, Jan; Frémond, Marie-Louise; Crow, Mary K.; Ronnblom, Lars; Conaghan, P.G.; Versnel, Marjan; Vital, Ed (Journal article; Peer reviewed, 2023)
      Objectives: To systematically review the literature for assay methods that aim to evaluate type I interferon (IFN-I) pathway activation and to harmonise-related terminology. Methods: Three databases were searched for ...