Browsing Department of Clinical Science by Journals "American Journal of Clinical Nutrition"
Now showing items 1-6 of 6
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B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study
(Journal article; Peer reviewed, 2023)Background Calcium channel blockers (CCBs) are used for the treatment of cardiovascular disease (CVD), including angina pectoris, and hypertension; however, the effect on survival remains uncertain. CCBs impair fibrinolysis ... -
Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations
(Peer reviewed; Journal article, 2017-06)Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the ... -
A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
(Journal article; Peer reviewed, 2021)Background Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5′-phosphate (PLP) is a commonly used measure of vitamin B6 status. ... -
Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease
(Journal article; Peer reviewed, 2019)Background Elevated circulating cystathionine levels are related to atherosclerotic cardiovascular disease, a leading cause of death globally. Objective We investigated whether plasma cystathionine was associated with ... -
Tryptophan catabolites as metabolic markers of vitamin B-6 status evaluated in cohorts of healthy adults and cardiovascular patients
(Journal article; Peer reviewed, 2020)Background Vitamin B-6 status is routinely measured as pyridoxal 5′-phosphate (PLP) in plasma. Low concentrations of PLP are associated with rheumatic, cardiovascular, and neoplastic diseases. We have previously shown ... -
Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat-a randomized controlled dietary intervention study
(Peer reviewed; Journal article, 2019-04-26)Background: Replacing dietary saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFA) reduces the plasma low-density lipoprotein (LDL) cholesterol and subsequently the risk of cardiovascular disease. However, ...