Blar i Department of Clinical Science på tidsskrift "Translational Psychiatry"
Viser treff 1-18 av 18
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Bidirectional genetic overlap between autism spectrum disorder and cognitive traits
(Journal article; Peer reviewed, 2023)Autism spectrum disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational ... -
Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking
(Journal article; Peer reviewed, 2021)Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and associated ... -
Differences in white blood cell proportions between schizophrenia cases and controls are influenced by medication and variations in time of day
(Journal article; Peer reviewed, 2023)Cases with schizophrenia (SCZ) and healthy controls show differences in white blood cell (WBC) counts and blood inflammation markers. Here, we investigate whether time of blood draw and treatment with psychiatric medications ... -
Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?
(Journal article; Peer reviewed, 2023)Parental genes may indirectly influence offspring psychiatric outcomes through the environment that parents create for their children. These indirect genetic effects, also known as genetic nurture, could explain individual ... -
An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD
(Journal article; Peer reviewed, 2022)Patients with a severe mental disorder report significantly higher levels of childhood trauma (CT) than healthy individuals. Studies have suggested that CT may affect brain plasticity through epigenetic mechanisms and ... -
Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes
(Journal article; Peer reviewed, 2021)Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD), despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP remain largely unknown. We investigated polygenic ... -
Genome-wide analysis of anorexia nervosa and major psychiatric disorders and related traits reveals genetic overlap and identifies novel risk loci for anorexia nervosa
(Journal article; Peer reviewed, 2023)Anorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and ... -
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia
(Journal article; Peer reviewed, 2021)While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ... -
Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits
(Journal article; Peer reviewed, 2020)Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study (GWAS) of CLZ serum ... -
Identification of pleiotropy at the gene level between psychiatric disorders and related traits
(Journal article; Peer reviewed, 2021)Major mental disorders are highly prevalent and make a substantial contribution to the global disease burden. It is known that mental disorders share clinical characteristics, and genome-wide association studies (GWASs) ... -
Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis
(Journal article; Peer reviewed, 2022)Several lines of evidence implicate immune abnormalities in the pathophysiology of severe mental disorders (SMD) and comorbid mental disorders. Here, we use the data from genome-wide association studies (GWAS) of autoimmune ... -
The impact of placental genomic risk for schizophrenia and birth asphyxia on brain development
(Journal article; Peer reviewed, 2023)The placenta plays a role in fetal brain development, and pregnancy and birth complications can be signs of placental dysfunction. Birth asphyxia is associated with smaller head size and higher risk of developing schizophrenia ... -
Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain
(Journal article; Peer reviewed, 2022)The gene ankyrin-3 (ANK3) has been consistently associated with bipolar disorder (BD) in several genome-wide association studies (GWAS). The exact molecular mechanisms underlying this genetic association remain unknown. ... -
No replication of previously reported association with genetic variants in the T cell receptor alpha (TRA) locus for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
(Journal article; Peer reviewed, 2022)Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with a variety of symptoms such as post-exertional malaise, fatigue, and pain, but where aetiology and pathogenesis are unknown. An increasing number ... -
No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank
(Journal article; Peer reviewed, 2023)The 15q11.2 BP1-BP2 copy number variant (CNV) is associated with altered brain morphology and risk for atypical development, including increased risk for schizophrenia and learning difficulties for the deletion. However, ... -
Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature neutrophil cells with association to lipid changes
(Journal article; Peer reviewed, 2023)Schizophrenia (SCZ) and bipolar disorder (BD) share clinical characteristics, genetic susceptibility, and immune alterations. We aimed to identify differential transcriptional patterns in peripheral blood cells of patients ... -
Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls
(Journal article; Peer reviewed, 2020-11)Cognitive impairments are considered core features in schizophrenia and other psychotic disorders. Cognitive impairments are, to a lesser degree, also documented in healthy first-degree relatives. Although recent studies ... -
Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors
(Journal article; Peer reviewed, 2021)Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and coronary artery disease (CAD). The conditional/conjunctional false discovery rate method (cond/conjFDR) was applied to genome wide ...