Department of Clinical Science: Recent submissions
Now showing items 581-600 of 2318
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Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation
(Journal article; Peer reviewed, 2022)Background: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, characterized by mononuclear cell infiltrates in the salivary and lacrimal glands, leading to glandular atrophy and dryness. Patient heterogeneity ... -
Randomized implementation of a primary human papillomavirus testing-based cervical cancer screening protocol for women 34 to 69 years in Norway
(Journal article; Peer reviewed, 2022)Background: Cervical cancer screening programs are facing a programmatic shift where screening protocol based on human papillomavirus testing (HPV-Screening protocol) is replacing the liquid-based cytology (LBC-Screening ... -
Eksamensformer i de norske medisinstudiene
(Journal article; Peer reviewed, 2022)BAKGRUNN Det finnes ingen samlet oversikt over hvilke eksamensformer som er i bruk i de norske medisinstudiene. I denne studien har vi kartlagt hvilke eksamensformer som er i bruk, og analysert studieledelsenes begrunnelser ... -
Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood
(Journal article; Peer reviewed, 2022)Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the genetic relationship between schizophrenia and brain volumetric ... -
Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells
(Journal article; Peer reviewed, 2022)Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s cases of ... -
Multimarker profiling identifies protective and harmful immune processes in heart failure: Findings from BIOSTAT-CHF
(Journal article; Peer reviewed, 2022)Aims The exploration of novel immunomodulatory interventions to improve outcome in heart failure (HF) is hampered by the complexity/redundancies of inflammatory pathways, which remain poorly understood. We thus aimed to ... -
Thrombectomy in large vessel occlusion stroke—Does age matter?
(Journal article; Peer reviewed, 2022)Objectives Endovascular treatment (EVT) is the gold standard treatment for emergent large vessel occlusion (LVO). The benefit of EVT for emergent LVO in elderly patients (>80 years old) is still debated as they have been ... -
Shared etiology of type 1 diabetes and Hashimoto’s thyroiditis: a population-based twin study
(Journal article; Peer reviewed, 2022)Objective Type 1 diabetes and Hashimoto’s thyroiditis frequently cluster in individuals and in families, indicating shared origins. The objective of this study was to investigate familial co-aggregation of these diseases ... -
Humanized Ovarian Cancer Patient-Derived Xenografts for Improved Preclinical Evaluation of Immunotherapies
(Journal article; Peer reviewed, 2022)High-grade serous ovarian cancer (HGSOC) has poor prognosis and new treatment modalities are needed. Immunotherapy, with checkpoint inhibitors, have demonstrated limited impact. To evaluate the suitability for immunotherapeutics, ... -
Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe
(Journal article; Peer reviewed, 2022-06-01)Immune checkpoint targeting immunotherapy has revolutionized the treatment of certain cancers in the recent years. Determination of the status of immune checkpoint expression in particular cancers may assist decision making. ... -
Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients
(Journal article; Peer reviewed, 2022-06-13)Allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies. However, this treatment is associated with severe treatment-related morbidity and mortality. The metabolic status of ... -
NPM1-Mutated Patient-Derived AML Cells Are More Vulnerable to Rac1 Inhibition
(Journal article; Peer reviewed, 2022)The prognosis of acute myeloid leukemia (AML) is poor, especially for the elderly population. Targeted therapy with small molecules may be a potential strategy to overcome chemoresistance and improve survival in AML. We ... -
Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts
(Journal article; Peer reviewed, 2022)Objective: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women. Design: Postmenopausal women were categorized ... -
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
(Journal article; Peer reviewed, 2022)Background Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed ... -
Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis
(Journal article; Peer reviewed, 2022)Several lines of evidence implicate immune abnormalities in the pathophysiology of severe mental disorders (SMD) and comorbid mental disorders. Here, we use the data from genome-wide association studies (GWAS) of autoimmune ... -
Corticosteroids and superinfections in COVID-19 patients on invasive mechanical ventilation
(Journal article; Peer reviewed, 2022)Objectives To determine the incidence and characteristics of superinfections in mechanically ventilated COVID-19 patients, and the impact of dexamethasone as standard therapy. Methods This multicentre, observational, ... -
Sepsis and antibiotic exposure in the neonatal period
(Doctoral thesis, 2022-09-30)Bakgrunn: Neonatalperioden (første 28 levedager) er den perioden i livet med høyest risiko for å utvikle sepsis. Tidlig nyfødt-sepsis (oppvekst i blodkultur innen første tre levedager) er assosiert med høy morbiditet og ... -
Distinct pathophysiological pathways in women and men with heart failure
(Journal article; Peer reviewed, 2022)Aims: Clinical differences between women and men have been described in heart failure (HF). However, less is known about the underlying pathophysiological mechanisms. In this study, we compared multiple circulating biomarkers ... -
Effects of sildenafil on symptoms and exercise capacity for heart failure with reduced ejection fraction and pulmonary hypertension (the SilHF study): a randomized placebo-controlled multicentre trial
(Journal article; Peer reviewed, 2022)Aims: Pulmonary hypertension (PHT) may complicate heart failure with reduced ejection fraction (HFrEF) and is associated with a substantial symptom burden and poor prognosis. Sildenafil, a phosphodiesterase-5 (PDE-5) ... -
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
(Journal article; Peer reviewed, 2022)Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect ...