Department of Clinical Science: Nye registreringer

Viser treff 521-540 av 2318

    • Symptom burden and immune dynamics 6 to 18 months following mild SARS-CoV-2 infection -a case-control study 

      Fjelltveit, Elisabeth Berg; Blomberg, Bjørn; Kuwelker, Kanika; Zhou, Fan; Onyango, Therese Bredholt; Brokstad, Karl Albert; Elyanow, Rebecca G; Kaplan, Ian; Tøndel, Camilla; Mohn, Kristin Greve-Isdahl; Özgümüs, Türküler; Cox, Rebecca Jane; Langeland, Nina (Journal article; Peer reviewed, 2022)
      Background The burden and duration of persistent symptoms after nonsevere coronavirus disease 2019 (COVID-19) remains uncertain. This study aimed to assess postinfection symptom trajectories in home-isolated COVID-19 cases ...

    • Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis 

      Braadland, Peder Rustøen; Schneider, Kai Markus; Bergquist, Annika; Molinaro, Antonio; Lövgren-Sandblom, Anita; Henricsson, Marcus; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Trautwein, Christian; Hov, Johannes Espolin Roksund; Marschall, Hanns-Ulrich (Journal article; Peer reviewed, 2022)
      Background & Aims: Farnesoid X receptor (FXR) agonists and fibroblast growth factor 19 (FGF19) analogues suppress bile acid synthesis and are being investigated for their potential therapeutic efficacy in cholestatic liver ...

    • Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer 

      Meltzer, Sebastian; Negård, Anne; Bakke, Kine Mari; Hamre, Hanne Mari; Kersten, Christian; Hofsli, Eva; Guren, Marianne; Sorbye, Halfdan; Flatmark, Kjersti; Ree, Anne Hansen (Journal article; Peer reviewed, 2022)
      Background: Immune checkpoint blockade (ICB) results in radiologic tumour response dynamics that differ from chemotherapy efficacy measures and require an early signal of clinical utility. Methods: Previously untreated, ...

    • Glycated albumin and continuous glucose monitoring metrics across pregnancy in women with pre-gestational diabetes 

      Toft, Johanne Holm; Dalen, Ingvild; Skadberg, Øyvind; Gøransson, Lasse Gunnar; Økland, Inger; Bleskestad, Inger Hjørdis (Journal article; Peer reviewed, 2022)
      Introduction: Glycated albumin (GA), a biomarker reflecting short-term glycaemia, may be useful to assess glycaemic control in pregnancy. We examined the association between GA and continuous glucose monitoring (CGM) metrics ...

    • Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC) 

      Sommersten, Cathrine Horn; Laupsa-Borge, Johnny; Andersen, Amanda Iselin Olesen; Fasmer, Kristine Eldevik; Holmefjord, Mari-Anna Frydenlund; Revheim, Ingrid; Johannessen, Kristine Kjerpeseth; Næsheim, Nicole Tandrevold; Storås, Inghild; Leikanger, Trine; Amundsen, Kristin; Skjerve, Karoline Lyngstad; Lawrence-Archer, Laurence; Spjelkavik, Camilla; Haldorsen, Ingfrid S.; Lindseth, Inge Andreas; Dierkes, Jutta; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2022)
      Background & aims: Visceral adipose tissue (VAT) volume is associated with common lifestyle diseases. Dietary quality, including food matrix and degree of carbohydrate cellularity, as well as the carbohydrate/fat ratio, ...

    • Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway 

      Wang, Shan; Rhijn, Jon-Ruben van; Akkouh, Ibrahim Ahmed; Kogo, Naoki; Maas, Nadine; Bleeck, Anna; Ortiz, Irene Santisteban; Lewerissa, Elly; Wu, Ka Man; Schoenmaker, Chantal; Djurovic, Srdjan; van Bokhoven, Hans; Kleefstra, Tjitske; Nadif Kasri, Nael; Schubert, Dirk (Journal article; Peer reviewed, 2022)
      Heterozygous loss-of-function (LoF) mutations in SETD1A, which encodes a subunit of histone H3 lysine 4 methyltransferase, cause a neurodevelopmental syndrome and increase the risk for schizophrenia. Using CRISPR-Cas9, we ...

    • The neutral amino acid transporter SLC7A10 in adipose tissue, obesity and insulin resistance 

      Jersin, Regine Åsen; Jonassen, Laura Roxana; Dankel, Simon N (Journal article; Peer reviewed, 2022)
      Obesity, insulin resistance and type 2 diabetes represent major global health challenges, and a better mechanistic understanding of the altered metabolism in these conditions may give improved treatment strategies. SLC7A10, ...

    • High circulating levels of the homeostatic chemokines CCL19 and CCL21 predict mortality and disease severity in Covid-19 

      Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet; Lerum, Tøri Vigeland; Kaarbø, Mari; Heggelund, Lars; Holten, Aleksander Rygh; Finbråten, Ane-Kristine; Muller, Karl Erik; Mathiessen, Alexander; Bøe, Simen; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Lind, Andreas; Dudman, Susanne; Nezvalova-Henriksen, Katerina; Müller, Fredrik; Skjønsberg, Ole Henning; Trøseid, Marius; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Dahl, Tuva Børresdatter; Ueland, Thor (Journal article; Peer reviewed, 2022)
      Background Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators of tissue inflammation, but ...

    • Comparison of ultrasound vector flow imaging and CFD simulations with PIV measurements of flow in a left ventricular outflow trackt phantom - Implications for clinical use and in silico studies 

      Leinan, Paul Roger; Grønli, Thomas; Skjetne, Paal; Wigen, Morten Smedsrud; Urheim, Stig; Løvstakken, Lasse; Dahl, Sigrid Kaarstad (Journal article; Peer reviewed, 2022)
      In this study we have compared two modalities for flow quantification from measurement data; ultrasound (US) and shadow particle image velocimetry (PIV), and a flow simulation model using computational fluid dynamics (CFD). ...

    • Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases 

      Lundtoft, Christian; Pucholt, Pascal; Martin, Myriam; Bianchi, Matteo; Lundström, Emeli; Eloranta, Maija-Leena; Sandling, Johanna K.; Sjöwall, Christopher; Jönsen, Andreas; Gunnarsson, Iva; Rantapää-Dahlqvist, Solbritt; Bengtsson, Anders A.; Leonard, Dag; Baecklund, Eva; Jonsson, Roland; Hammenfors, Daniel; Forsblad-d'Elia, Helena; Eriksson, Per; Mandl, Thomas; Magnusson Bucher, Sara; Norheim, Katrine Brække; Johnsen, Svein Joar Auglæn; Omdal, Roald; Kvarnström, Marika; Wahren Herlenius, Marie Elisabeth; Notarnicola, Antonella; Andersson, Anna Helena; Molberg, Øyvind; Diederichsen, Louise Pyndt; Almlöf, Jonas; Syvänen, Ann-Christine; Kozyrev, Sergey V.; Lindblad-Toh, Kerstin; Rönnblom, Lars; Brokstad, Karl Albert; Skarstein, Kathrine; Jonsson, Malin Viktoria; Appel, Silke; Aqrawi, Lara A.; Jensen, Janicke Liaaen; Palm, Øyvind; Nilsson, Birgitta Blakstad; Blom, Anna M.; Lundberg, Ingrid E.; Nordmark, Gunnel; Diaz-Gallo, Lina Marcela; Svenungsson, Elisabet; Rönnblom, Lars (Journal article; Peer reviewed, 2022)
      Objective Copy number variation of the C4 complement components, C4A and C4B, has been associated with systemic inflammatory autoimmune diseases. This study was undertaken to investigate whether C4 copy number variation ...

    • MicroRNA serum profiles and chronic graft-versus-host disease 

      Reikvam, Håkon; Vo, Anh Khoi; Johansen, Silje; Hemsing, Anette Lodvir; Haugland Solheim, Magne; Mosevoll, Knut Anders; Tvedt, Tor Henrik Anderson; Hatfield, Kimberley Joanne (Journal article; Peer reviewed, 2022)
      Chronic graft-versus-host disease (cGVHD) is the most common long-term complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). During the last decade, the interest of micro RNAs (miRNAs) in the ...

    • On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families 

      Eilertsen, Espen Moen; Gillespie Cheesman, Rosa Catherine; Ayorech, Ziada; Røysamb, Espen; Pingault, Jean-Baptiste; Njølstad, Pål Rasmus; Andreassen, Ole; Havdahl, Alexandra Karoline Saasen; McAdams, Tom A.; Torvik, Fartein Ask; Ystrøm, Eivind (Journal article; Peer reviewed, 2022)
      Background: Theoretical models of the development of childhood externalizing disorders emphasize the role of parents. Empirical studies have not been able to identify specific aspects of parental behaviors explaining a ...

    • Living With Ovarian Cancer: Transitions Lost in Translation 

      Gissum, Karen Rosnes; Drageset, Sigrunn; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Strand, Roger (Journal article, 2022)
      Background: Living with ovarian cancer involves uncertainty, fear of recurrence, and premature death while preparing for a life after treatment. The women depend on health care professionals while moving from being healthy ...

    • Fatigue: a frequent and biologically based phenomenon in newly diagnosed celiac disease 

      Skjellerudsveen, Berit Mære; Omdal, Roald; Hetta, Anne Kristine; Kvaløy, Jan Terje; Aabakken, Lars; Skoie, Inger Marie; Grimstad, Tore Bjørn (Journal article; Peer reviewed, 2022)
      Fatigue is increasingly recognized as a major complaint in patients with chronic inflammatory and autoimmune diseases. Although fatigue is assumed to represent a significant problem in celiac disease, existing knowledge ...

    • Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome 

      Keindl, Magdalena; Davies, Richard Allan; Bergum, Brith; Brun, Johan Gorgas; Hammenfors, Daniel; Jonsson, Roland; Lyssenko, Valeriya; Appel, Silke (Journal article; Peer reviewed, 2022)
      Background Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune diseases. ...

    • The Performances of Three Commercially Available Assays for the Detection of SARS‐CoV‐2 Antibodies at Different Time Points Following SARS‐CoV‐2 Infection 

      Syre, Heidi; Obreque, Marius Eduardo Brå; Dalen, Ingvild; Riis, Åse Garløv; Berg, Åse; Löhr, Iren Høyland; Sundal, Jon; Kleppe, Lars Kåre Selland; Vadla, May Sissel; Lenning, Ole Bernt; Olofsson, Jan Stefan; Mohn, Kristin Greve-Isdahl; Tøndel, Camilla; Blomberg, Bjørn; Trieu, Mai Chi; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2022)
      The aim of this study was to evaluate the performances of three commercially available antibody assays for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies at different time points ...

    • Concomitant Hemophagocytic Lymphohistiocytosis and Cytomegalovirus Disease: A Case Based Systemic Review 

      Rolsdorph, Linn; Mosevoll, Knut Anders; Helgeland, Lars; Reikvam, Håkon (Journal article; Peer reviewed, 2022)
      Background: Hemophagocytic lymphohistiocytosis (HLH) is an immune mediated life-threatening condition. It is driven by an overactivation of the immune system and causes inflammatory tissue damage potentially leading to ...

    • Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure 

      Inciardi, Riccardo M.; Pagnesi, Matteo; Lombardi, Carlo M.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Lang, Chim C.; Ng, Leong L.; Pellicori, Pierpaolo; Ponikowski, Piotr; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Solomon, Scott D.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2022)
      Aims Limited data exist regarding the prognostic relevance of changes in left atrial (LA) dimensions in patients with heart failure (HF). We assessed changes in LA dimension and their relation with outcomes after optimization ...

    • QRS fragmentation is associated with increased risk of ventricular arrhythmias in high-risk patients; Data from the SMASH 1 Study 

      Sourour, Nur; Riveland, Egil Aarstad; Rømo, Terje; Næsgaard, Patrycja; Kjekshus, Harald; Larsen, Alf Inge; Omland, Torbjørn; Røsjø, Helge Rørvik; Myhre, Peder Langeland (Journal article; Peer reviewed, 2022)
      Introduction QRS fragmentation (fQRS), defined as the presence of additional spikes within the QRS complex, has been associated with myocardial conduction abnormalities and arrhythmogenicity. Objective We aimed to ...

    • Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies 

      Trøseid, Marius; Dahl, Tuva Børresdatter; Holter, Jan Cato; Kildal, Anders Benjamin; Murphy, Sarah Louise Mikalsen; Yang, Kuan; Quiles Jimenez, Ana Maria Teresa; Heggelund, Lars; Muller, Karl Erik; Tveita, Anders Aune; Michelsen, Annika Elisabet; Bøe, Simen; Holten, Aleksander Rygh; Hoel, Hedda Benedicte; Mathiessen, Alexander; Aaløkken, Trond Mogens; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Nezvalova-Henriksen, Katerina; Lerum, Tøri Vigeland; Müller, Fredrik; Skjønsberg, Ole Henning; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Ueland, Thor (Journal article; Peer reviewed, 2022)
      Background: T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown. Objectives: To investigate ...