Department of Clinical Science: Nye registreringer
Viser treff 301-320 av 2318
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Identification of acute coronary syndrome in the era of high-sensitivity troponin assays
(Doctoral thesis, 2023-06-02)Bakgrunn: Det er mulig å bedre pasientflyt og diagnostisk presisjon ved utredning av pasienter med mistenkt akutt koronarsyndrom (AKS). Konsentrasjonen av kardialt troponin (cTnT eller cTnI) kan benyttes til å forutse ... -
Intrauterine and genetic risk factors for proliferative diabetic retinopathy
(Doctoral thesis, 2022-05-13)Diabetes is a complex progressive metabolic disorder characterized by hyperglycemia and caused by different etiopathogenic factors. Individuals with diabetes have heterogeneous clinical representation and increased risk ... -
Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?
(Journal article; Peer reviewed, 2023)Parental genes may indirectly influence offspring psychiatric outcomes through the environment that parents create for their children. These indirect genetic effects, also known as genetic nurture, could explain individual ... -
Mitral annular dynamics are influenced by left ventricular load and contractility in an acute animal model
(Journal article; Peer reviewed, 2023)The purpose of this study was to investigate the effects of loading conditions and left ventricular (LV) contractility on mitral annular dynamics. In 10 anesthetized pigs, eight piezoelectric transducers were implanted ... -
Cryptosporidiosis in low-resource healthcare settings : Near-patient diagnostics, risk factors, and parasite shedding dynamics in young Ethiopian children
(Doctoral thesis, 2023-04-28)Bakgrunn: Tarmparasitten Cryptosporidium er en ledende årsak til diaré og dødsfall hos småbarn i lavinntektsland. Målretta behandling trengs, men forutsetter presise diagnostiske tester som er egna for ressursfattige ... -
Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)
(Journal article; Peer reviewed, 2023)Background Guidance to improve fertility includes reducing alcohol and caffeine consumption, achieving healthy weight-range and stopping smoking. Advice is informed by observational evidence, which is often biased by ... -
Strong Association between Diarrhea and Concentration of Enterotoxigenic Escherichia coli Strain TW10722 in Stools of Experimentally Infected Volunteers
(Journal article; Peer reviewed, 2023)Enterotoxigenic Escherichia coli (ETEC) strains are a major cause of diarrheal illness in children and travelers in low- and middle-income countries. When volunteers are infected with ETEC strains, as part of experimental ... -
A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland
(Journal article; Peer reviewed, 2023)Background: The genetic disease architecture of Inuit includes a large number of common high-impact variants. Identification of such variants contributes to our understanding of the genetic aetiology of diseases and improves ... -
Use of inhaled ipratropium bromide to improve exercise-induced laryngeal obstruction cannot be recommended
(Journal article; Peer reviewed, 2023)Introduction: Exercise-induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young adults. Current management generally consists of breathing advice, speech therapy, inspiratory muscle ... -
Durable immune responses after BNT162b2 vaccination in home-dwelling old adults
(Journal article; Peer reviewed, 2023)Objectives Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We comprehensively analyzed the durability of humoral and cellular immune responses after BNT162b2 vaccination and SARS-CoV-2 infection ... -
Risk of Subsequent Preeclampsia by Maternal Country of Birth: A Norwegian Population-Based Study
(Journal article; Peer reviewed, 2023)In this nationwide population-based study, we investigated the associations of preeclampsia in the first pregnancy with the risk of preeclampsia in the second pregnancy, by maternal country of birth using data from the ... -
Making wise decisions for completion thyroidectomies
(Journal article; Peer reviewed, 2022) -
In depth analyses of peripheral blood immune cell populations in patients with psoriasis - effect of biological treatment and alternative medicine
(Doctoral thesis, 2023-04-26)Psoriasis er en kronisk immun-mediert sykdom i huden med systemisk betennelse og ledsagende komorbiditeter. Selv om alvorlighetsgraden av sykdommen kan variere over tid, lider de fleste pasienter med psoriasis av mild til ... -
Bounding the average causal effect in Mendelian randomisation studies with multiple proposed instruments: An application to prenatal alcohol exposure and attention deficit hyperactivity disorder
(Journal article; Peer reviewed, 2023)Background As large-scale observational data become more available, caution regarding causal assumptions remains critically important. This may be especially true for Mendelian randomisation (MR), an increasingly popular ... -
A novel concentrated, interdisciplinary group rehabilitation program for patients with chronic obstructive pulmonary disease: Protocol for a nonrandomized clinical intervention study
(Journal article; Peer reviewed, 2022)Background: Pulmonary rehabilitation has been demonstrated to be a highly effective treatment for people with chronic obstructive pulmonary disease (COPD). However, its availability is scarce worldwide, and new and ... -
The clinical use of mechanical insufflation-exsufflation in children with neuromuscular disorders in Europe
(Journal article; Peer reviewed, 2018)Mechanical insufflation-exsufflation (MI-E) is a strategy to treat pulmonary exacerbations in neuromuscular disorders (NMDs). Pediatric guidelines for optimal setting titration of MI-E are lacking and the settings used in ... -
Multidisciplinary approaches to identifying and managing global airways disease: Expert recommendations based on qualitative discussions
(Journal article; Peer reviewed, 2023)Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently co-exist and share pathologic features. Taking a “global” treatment approach benefits diagnosis and treatment of both, but care is often ... -
Strategies for improving Influenza vaccines: insights from the Influenza A H1N1 and SARS-CoV-2 pandemics
(Doctoral thesis, 2022-09-23)Influensa er et luftveisvirus som kan forårsake alvorlig sykdom og under stadig forandring (drift). Dagens influensavaksiner gir begrenset beskyttelse mot slike driftede influensavirus. Dette fører til at vaksinesammensetningen ... -
Polygenic risk modeling for prediction of epithelial ovarian cancer risk
(Journal article; Peer reviewed, 2022)Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance ... -
Clinical outcomes among young patients with Fabry disease who initiated agalsidase beta treatment before 30 years of age: An analysis from the Fabry registry
(Journal article; Peer reviewed, 2023)Background Clinical manifestations of classic Fabry disease (α-galactosidase A deficiency) usually occur in childhood, while complications involving major organs typically develop in adulthood. Outcomes of Fabry-specific ...