Browsing Department of Biomedicine by Journals "PLoS Biology"
Now showing items 1-2 of 2
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Atomic view into plasmodium actin polymerization, ATP hydrolysis, and fragmentation
(Peer reviewed; Journal article, 2019)Plasmodium actins form very short filaments and have a noncanonical link between ATP hydrolysis and polymerization. Long filaments are detrimental to the parasites, but the structural factors constraining Plasmodium ... -
Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics
(Journal article; Peer reviewed, 2023)With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red ...