Browsing Department of Biomedicine by Document Types "Peer reviewed"
Now showing items 1-20 of 602
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The 14-3-3 proteins in regulation of cellular metabolism
(Peer reviewed; Journal article, 2011-09)Thirty years ago, it was discovered that 14-3-3 proteins could activate enzymes involved in amino acid metabolism. In the following decades, 14-3-3s have been shown to be involved in many different signaling pathways that ... -
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
(Journal article; Peer reviewed, 2021)Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers ... -
Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat
(Journal article; Peer reviewed, 2021)We discovered high Na+ and water content in the skin of newborn Sprague–Dawley rats, which reduced ~ 2.5-fold by 7 days of age, indicating rapid changes in extracellular volume (ECV). Equivalent changes in ECV post birth ... -
An accessible proteogenomics informatics resource for cancer researchers
(Peer reviewed; Journal article, 2017)Proteogenomics has emerged as a valuable approach in cancer research, which integrates genomic and transcriptomic data with mass spectrometry–based proteomics data to directly identify expressed, variant protein sequences ... -
Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control
(Peer reviewed; Journal article, 2019)Actin is one of the most abundant proteins in eukaryotic cells and the main component of the microfilament system. It plays essential roles in numerous cellular activities including muscle contraction, maintenance of cell ... -
Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells
(Peer reviewed; Journal article, 2012-03-27)Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the ... -
Activation-induced chromatin reorganization in neurons depends on HDAC1 activity
(Journal article; Peer reviewed, 2022)Spatial chromatin organization is crucial for transcriptional regulation and might be particularly important in neurons since they dramatically change their transcriptome in response to external stimuli. We show that ... -
Acute Intermittent Porphyria: An Overview of Therapy Developments and Future Perspectives Focusing on Stabilisation of HMBS and Proteostasis Regulators
(Journal article; Peer reviewed, 2021)Acute intermittent porphyria (AIP) is an autosomal dominant inherited disease with low clinical penetrance, caused by mutations in the hydroxymethylbilane synthase (HMBS) gene, which encodes the third enzyme in the haem ... -
ADHD symptoms in neurometabolic diseases: Underlying mechanisms and clinical implications
(Journal article; Peer reviewed, 2021)Neurometabolic diseases (NMDs) are typically caused by genetic abnormalities affecting enzyme functions, which in turn interfere with normal development and activity of the nervous system. Although the individual disorders ... -
ADP-ribosyltransferases, an update on function and nomenclature
(Journal article; Peer reviewed, 2021)ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in intra- ... -
Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review
(Peer reviewed; Journal article, 2016)Objective: To systematically review, synthesize, and appraise available evidence, connecting adult ADHD (aADHD) with somatic disease. Method: Embase, Psychinfo, and Medline databases were searched for studies published ... -
Age-dependent association between protein expression of the embryonic stem cell marker Cripto-1 and survival of glioblastoma patients
(Peer reviewed; Journal article, 2013-12)Exploring the re-emergence of embryonic signaling pathways may reveal important information for cancer biology. Nodal is a transforming growth factor-β (TGF-β)-related morphogen that plays a critical role during embryonic ... -
Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors
(Peer reviewed; Journal article, 2014-06-26)Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during human mammary epithelial aging for reasons not understood. Multipotent progenitors from women aged <30 years were exposed to ... -
AII amacrine cells: quantitative reconstruction and morphometric analysis of electrophysiologically identified cells in live rat retinal slices imaged with multi-photon excitation microscopy
(Peer reviewed; Journal article, 2016-02)AII amacrine cells have been found in all mammalian retinas examined and play an important role for visual processing under both scotopic and photopic conditions. Whereas ultrastructural investigations have provided a ... -
Altered DNA methylation profile in Norwegian patients with Autoimmune Addison’s Disease
(Peer reviewed; Journal article, 2014-03-22)Autoimmune Addison's Disease (AAD) is an endocrine and immunological disease of uncertain pathogenesis resulting from the immune system's destruction of the hormone producing cells of the adrenal cortex. The underlying ... -
Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways
(Peer reviewed; Journal article, 2017)Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by ... -
AMPA receptors at ribbon synapses in the mammalian retina: kinetic models and molecular identity
(Peer reviewed; Journal article, 2018)In chemical synapses, neurotransmitter molecules released from presynaptic vesicles activate populations of postsynaptic receptors that vary in functional properties depending on their subunit composition. Differential ... -
Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer
(Peer reviewed; Journal article, 2011-01-31)Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder, melanoma, pancreas and breast cancer, suggesting that 20q amplification may play a causal role in tumorigenesis. According to an ... -
AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion
(Journal article; Peer reviewed, 2020)The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic ... -
Anabaenolysins, Novel Cytolytic Lipopeptides from Benthic Anabaena Cyanobacteria
(Peer reviewed; Journal article, 2012-07-19)Two novel cyclic lipopeptides, anabaenolysin A and anabaenolysin B, were isolated from two benthic cyanobacterial strains of the genus Anabaena. This novel class of cyanobacterial lipopeptides has a general structure of a ...