Blar i Department of Biomedicine på emneord "Biomedicine"
Viser treff 1-11 av 11
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Arc protein-protein interactions in long-term potentiation in the rat dentate gyrus in vivo
(Master thesis, 2014-06-02)Synaptic plasticity is the ability of neuronal synapses to change in strength over time, and is considered to be a foundation for learning and memory. Long-term potentiation (LTP) is a widely studied form of synaptic ... -
The effect of hyperbaric oxygen treatment on malignant progression in different breast cancer models in vivo
(Master thesis, 2016-07-01)Background: Hypoxia is an important feature of most solid tumors and has shown to serve as a mediator for aggressive tumor growth and malignant progression of cancer. A correlation between low oxygen tension in tumors and ... -
The in vivo effect of integrin α11-deficiency and PDGFR inhibition in breast cancer
(Master thesis, 2018-10-19)Background: The tumor microenvironment is a major contributor to breast cancer progression. The abnormal composition of the extracellular matrix and its deregulated interactions with stromal cells, which is characterizing ... -
In-vitro characterization of STUB1 mutations in recessively inherited spinocerebellar ataxia-16
(Master thesis, 2016-05-31)Autosomal Recessive Cerebellar Ataxia (ARCA) develops as a result of inefficient protein turnover and further accumulation of damaged proteins inside the cells. Some of mutations associated with ARCA are identified in the ... -
Insights into the cellular role of Serine19 phosphorylation in tyrosine hydroxylase
(Master thesis, 2016-06-01)Tyrosine hydroxylase (TH) is the rate limiting enzyme that catalyzes the first step in the biosynthesis of catecholamines. The posttranslational modification of its regulatory domain controls the regulation of TH enzyme ... -
Investigating the role of vitamin K in Axl-mediated melanoma progression and chemotherapeutic resistance
(Master thesis, 2018-06-29)Metastatic melanoma is a highly aggressive cancer with a very poor prognosis and current therapies remain inadequate. Norway is among the top five countries with the highest incidence of melanoma. Malignant cells carry ... -
Investigation of protein signalling pathways activated by sonoporation in cancer
(Master thesis, 2018-06-29)Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. patients with a metastatic PDAC only survive 3 – 5 months if left untreated and less than 25% of diagnosed patients are eligible for ... -
POU3f2 in human gliomas - Expression pattern and functional role
(Master thesis, 2014-06-02)Gliomas are tumors of the central nervous system (CNS). They are responsible for about 28% of all central nervous system tumors and for 80% of all malignant brain tumors. The most commonly used classification and grading ... -
Role of Caveolin-1 in Hypoxia and Proneural to Mesenchymal Transition of Glioblastoma
(Master thesis, 2018-06-29)Glioblastomas (GBM), a grade IV astrocytoma, is the most common and aggressive primary brain tumors in adults, associated with short survival and uniformly fatal outcome irrespective of treatment. GBM is highly heterogeneous ... -
Sensing foul AIRE: Investigating possible reporter genes for AIRE mutations
(Master thesis, 2018-06-29)The autoimmune regulator protein, known as AIRE, is a potent transcriptional regulator active in medullary thymic epithelial cells (mTECs) of the thymus, where it is able to switch on the expression of thousands of genes ... -
Toxicity and tropism of oncolytic VSV vectors in glioblastoma gene therapy
(Master thesis, 2012-11-05)Glioblastoma multiforme is the most common and most fatal primary brain tumor in adults. Despite using advanced conventional therapeutic approaches like surgical resection, radiotherapy and chemotherapy only marginal ...