Browsing Department of Biomedicine by Subject "751910"

Impact of hypoxia on the expression of cell line markers and behavior of cultured glioma cell lines

Leiss, Lina Wik (Master thesis, 2011-06-01)

Glioblastoma multiforme (GBM) constitute over 50 % of primary brain tumors in adults. The tumor is heterogeneous and highly infiltrative. Its nature makes it extremely aggressive and incurable. Thus, today's treatment ...

In vitro and in vivo studies of a novel blood brain barrier permeabilizing peptide K16ApoE

Holte, Christopher Florian (Master thesis, 2016-05-30)

Brain metastasis is a common and severe complication arising in up to 40 % of cancer patients. The prognoses for patients with brain metastases are dismal, with a median treated survival of around 10 months. Treatment of ...

The in vitro effect of cytokine autoantibodies on Th17-differentiation and function

Iraji, Dorsa (Master thesis, 2023-06-01)

The in vivo effect of integrin α11-deficiency and PDGFR inhibition in breast cancer

Brodahl, Tore Andre (Master thesis, 2018-10-19)

Background: The tumor microenvironment is a major contributor to breast cancer progression. The abnormal composition of the extracellular matrix and its deregulated interactions with stromal cells, which is characterizing ...

In-vitro characterization of STUB1 mutations in recessively inherited spinocerebellar ataxia-16

Pakdaman, Yasaman (Master thesis, 2016-05-31)

Autosomal Recessive Cerebellar Ataxia (ARCA) develops as a result of inefficient protein turnover and further accumulation of damaged proteins inside the cells. Some of mutations associated with ARCA are identified in the ...

Insights into the cellular role of Serine19 phosphorylation in tyrosine hydroxylase

K C, Kunwar Jung (Master thesis, 2016-06-01)

Tyrosine hydroxylase (TH) is the rate limiting enzyme that catalyzes the first step in the biosynthesis of catecholamines. The posttranslational modification of its regulatory domain controls the regulation of TH enzyme ...

Investigating the role of vitamin K in Axl-mediated melanoma progression and chemotherapeutic resistance

Siraji, Muntequa Ishtiaq (Master thesis, 2018-06-29)

Metastatic melanoma is a highly aggressive cancer with a very poor prognosis and current therapies remain inadequate. Norway is among the top five countries with the highest incidence of melanoma. Malignant cells carry ...

Investigation of protein signalling pathways activated by sonoporation in cancer

Sundøy, Silje Maria (Master thesis, 2018-06-29)

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. patients with a metastatic PDAC only survive 3 – 5 months if left untreated and less than 25% of diagnosed patients are eligible for ...

Mass spectrometry-based proteomics of human cerebrospinal fluid. Biomarker discovery and verification in multiple sclerosis

Vethe, Heidrun (Master thesis, 2012-06-01)

The main focus of this study was to use mass spectrometry-based proteomics to study protein abundance in cerebrospinal fluid (CSF) to reveal proteins that could serve as biomarker candidates in multiple sclerosis (MScl). ...

Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo

Vieuille, Christel Marie (Master thesis, 2012-05-30)

Synaptic plasticity is defined as the ability of a neuronal synapse to change in strength, and is believed to be the basis of learning and memory. An example of synaptic plasticity, by far the most studied, is long-term ...

Molecular pathways of mitochondria transfer in Glioblastoma cells

Pinaz, Farzana Islam (Master thesis, 2024-06-03)

Glioblastoma (GBM) is a malignant brain tumor and the most aggressive form of brain cancer in adults. The aggressive nature and invasive properties of GBM cells contribute to the poor prognosis and increased rate of ...

New tools to enhance the detection of post-translational modifications: Development and application of a mass spectrometry-based proteomic software and of specific antibodies detecting propionylated lysines

Arntzen, Magnus Øverlie (Master thesis, 2009-08-02)

Mass spectrometry based proteomics has evolved into a powerful tool in characterising proteins and their respective function in the cell. A proteins cellular localisation, concentration and activity is regulated by several ...

Oral microbiome in a general population - The influence of sample site and sampling method

Jensen, Tuva Norderud (Master thesis, 2023-08-02)

Oral microbiome profiles reflect the sample types and methodology used to investigate them. The composition of microbes in the oral cavity is site specific. It can also vary due to differences in how a site is sampled. ...

POU3f2 in human gliomas - Expression pattern and functional role

Lellahi, Seyed Mohammad (Master thesis, 2014-06-02)

Gliomas are tumors of the central nervous system (CNS). They are responsible for about 28% of all central nervous system tumors and for 80% of all malignant brain tumors. The most commonly used classification and grading ...

Preparing for an influenza pandemic: Re-evaluating the use of the whole inactivated virus vaccine formulation. –A comparison of the immune responses after intramuscular or intranasal immunization with an influenza H5N1 whole inactivated virus vaccine in a murine model.

Trondsen, Monica (Master thesis, 2009-10-22)

Influenza is a highly contagious respiratory disease which infects millions of people every year around the world. Influenza viruses undergo continuous antigen change and annual vaccination is an effective prophylactic ...