Blar i Department of Biomedicine på forfatter "Birkeland, Even"
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Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway
Rahman, Mohummad Aminur; Engelsen, Agnete; Sarowar, Shahin; Bindesbøll, Christian; Birkeland, Even; Goplen, Dorota; Lotsberg, Maria Lie; Knappskog, Stian; Simonsen, Anne Gjøen; Enger, Martha (Journal article; Peer reviewed, 2022)Introduction: Glioblastoma (GBM) is invariably resistant to temozolomide (TMZ) chemotherapy. Inhibiting the proteasomal pathway is an emerging strategy to accumulate damaged proteins and inhibit their lysosomal degradation. ... -
The effects of phenylalanine and tyrosine levels on dopamine production in rat PC12 cells. Implications for treatment of phenylketonuria, tyrosinemia type 1 and comorbid neurodevelopmental disorders
Szigetvari, Peter Daniel; Patil, Sudarshan; Birkeland, Even; Kleppe, Rune; Haavik, Jan (Journal article; Peer reviewed, 2023)Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by mutations in the phenylalanine hydroxylase (PAH) gene, resulting in phenylalanine accumulation and impaired tyrosine production. In Tyrosinemia ... -
Human blood serum proteome changes after 6 hours of sleep deprivation at night
Bjørkum, Alvhild Alette; Duran, Ana Carasco; Berven, Frode Steingrimsen; Roy, Dola Sinha; Rosendahl, Karen; Birkeland, Even; Stuhr, Linda Elin Birkhaug (Journal article; Peer reviewed, 2021)Background The aim of this study was to discover significantly changed proteins in human blood serum after loss of 6 h sleep at night. Furthermore, to reveal affected biological process- and molecular function categories ... -
Quantitative proteome profiling reveals molecular hallmarks of egg quality in Atlantic halibut: impairments of transcription and protein folding impede protein and energy homeostasis during early development
Yilmaz, Ozlem; Mangor-Jensen, Anders; Harboe, Torstein; Drønen, Margareth Møgster; Mangor-Jensen, Ragnfrid; Mjaavatten, Olav; Birkeland, Even; Spriet, Endy; Sandven, Linda; Furmanek, Tomasz; Berven, Frode Steingrimsen; Wargelius, Anna; Norberg, Birgitta (Journal article; Peer reviewed, 2022)Background Tandem mass tag spectrometry (TMT labeling-LC-MS/MS) was utilized to examine the global proteomes of Atlantic halibut eggs at the 1-cell-stage post fertilization. Comparisons were made between eggs judged to ...