• GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity 

      Watson, Dionysios C.; Bayik, Defne; Storevik, Simon Humberto; Moreino, Shannon Sherwin; Sprowls, Samuel A.; Han, Jianhua; Augustsson, Mina Thue; Lauko, Adam; Sravya, Palavalasa; Røsland, Gro Vatne; Troike, Katie; Tronstad, Karl Johan; Wang, Sabrina; Sarnow, Katharina; Kay, Kristen; Lunavat, Taral; Silver, Daniel J.; Dayal, Sahil; Vareecal Joseph, Justin; Mulkearns-Hubert, Erin; Ystaas, Lars Andreas Rømo; Deshpande, Gauravi; Guyon, Joris; Zhou, Yadi; Magaut, Capucine R.; Seder, Juliana; Neises, Laura; Williford, Sarah E.; Meiser, Johannes; Scott, Andrew J.; Sajjakulnukit, Peter; Mears, Jason A.; Bjerkvig, Rolf; Chakraborty, Abhishek; Daubon, Thomas; Cheng, Feixiong; Lyssiotis, Costas A.; Wahl, Daniel R.; Hjelmeland, Anita B.; Hossain, Md Jubayer al; Miletic, Hrvoje; Lathia, Justin D. (Journal article; Peer reviewed, 2023)
      The transfer of intact mitochondria between heterogeneous cell types has been confirmed in various settings, including cancer. However, the functional implications of mitochondria transfer on tumor biology are poorly ...
    • Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes 

      Rigg, Emma Kayleigh; Wang, Jiwei; Xue, Zhiwei; Lunavat, Taral; Liu, Guowei; Hoang, Tuyen; Parajuli, Himalaya; Han, Mingzhi; Bjerkvig, Rolf; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Margue, Christiane; Nomigni, Miléne Tetsi; Utikal, Jochen; Miletic, Hrvoje; Sundstrøm, Terje; Ystaas, Lars Andreas Rømo; Li, Xingang; Thorsen, Frits (Journal article; Peer reviewed, 2023)
      Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late-stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis ...
    • Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma 

      Hossain, Jubayer; Latif, Md Abdul; Ystaas, Lars Andreas Rømo; Ninzima, Sandra; Riecken, Kristoffer; Muller, Arnaud; Azuaje, Fransisco; Vareecal Joseph, Justin; Talasila, Krishna Mukharji; Ghimire, Jiwan; Fehse, Boris; Bjerkvig, Rolf; Miletic, Hrvoje (Peer reviewed; Journal article, 2019)
      Background: Suicide gene therapy for malignant gliomas has shown encouraging results in the latest clinical trials. However, prodrug application was most often restricted to short-term treatment (14 days), especially when ...
    • Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry 

      Kulkarni, Amit; Ferreira, Tiago; Bretscher, Clemens; Grewenig, Annabel; El-Andaloussi, Nazim; Bonifati, Serena; Marttila, Tiina; Palissot, Valèrie; Hossain, Jubayer A.; Azuaje, Francisco; Miletic, Hrvoje; Ystaas, Lars Andreas Rømo; Golebiewska, Anna; Niclou, Simone Pierrette; Roeth, Ralf; Niesler, Beate; Weiss, Amélie; Brino, Laurent; Marchini, Antonio (Journal article; Peer reviewed, 2021)
      H-1 parvovirus (H-1PV) is a promising anticancer therapy. However, in-depth understanding of its life cycle, including the host cell factors needed for infectivity and oncolysis, is lacking. This understanding may guide ...
    • Oncolytic H-1 Parvovirus Hijacks Galectin-1 to Enter Cancer Cells 

      Ferreira, Tiago; Kulkarni, Amit; Bretscher, Clemens; Nazarov, Petr V.; Hossain, Md Jubayer al; Ystaas, Lars Andreas Rømo; Miletic, Hrvoje; Röth, Ralph; Niesler, Beate; Marchini, Antonio (Journal article; Peer reviewed, 2022)
      Clinical studies in glioblastoma and pancreatic carcinoma patients strongly support the further development of H-1 protoparvovirus (H-1PV)-based anticancer therapies. The identification of cellular factors involved in the ...