• Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment 

      Lillebostad, Peder August Gudmundsen; Raasakka, Arne; Hjellbrekke, Silje Johannessen; Patil, Sudarshan; Røstbø, Trude Kvalnes; Hollås, Hanne; Sakya, Siri; Szigetvari, Peter Daniel; Vedeler, Anni; Kursula, Petri (Journal article; Peer reviewed, 2020)
      The functions of the annexin family of proteins involve binding to Ca2+, lipid membranes, other proteins, and RNA, and the annexins share a common folded core structure at the C terminus. Annexin A11 (AnxA11) has a long ...
    • Targeting the Class A Carbapenemase GES-5 via Virtual Screening 

      Klein, Raphael; Cendron, Laura; Montanari, Maria; Bellio, Pierangelo; Celenza, Giuseppe; Maso, Lorenzo; Tondi, Donatella; Brenk, Ruth (Journal article; Peer reviewed, 2020)
      The worldwide spread of β-lactamases able to hydrolyze last resort carbapenems contributes to the antibiotic resistance problem and menaces the successful antimicrobial treatment of clinically relevant pathogens. Class A ...
    • Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25 

      Monnè, Magnus; Nikiforov, Andrey; Heiland, Ines; Agrimi, Gennaro; Ziegler, Mathias; Palmieri, Ferdinando (Journal article; Peer reviewed, 2021)
      Subcellular compartmentation is a fundamental property of eukaryotic cells. Communication and metabolic and regulatory interconnectivity between organelles require that solutes can be transported across their surrounding ...