Blar i Department of Biomedicine på tidsskrift "Cancers"

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    • Challenges and Prospects for Designer T and NK Cells in Glioblastoma Immunotherapy 

      Arnesen, Victoria Smith; Gras Navarro, Andrea; Enger, Martha (Journal article; Peer reviewed, 2021)
      Glioblastoma (GBM) is the most prevalent, aggressive primary brain tumour with a dismal prognosis. Treatment at diagnosis has limited efficacy and there is no standardised treatment at recurrence. New, personalised treatment ...

    • Comparing Tumor Cell Invasion and Myeloid Cell Composition in Compatible Primary and Relapsing Glioblastoma 

      Zhao, Dongxu; Zhang, Huabin; Uyar, Ramazan; Hossain, Jubayer A.; Miletic, Hrvoje; Tonn, Jörg-Christian; Glass, Rainer; Kälin, Roland E. (Journal article; Peer reviewed, 2021)
      Glioblastoma (GBM) recurrence after treatment is almost inevitable but addressing this issue with adequate preclinical models has remained challenging. Here, we introduce a GBM mouse model allowing non-invasive and scalable ...

    • The effect of stromal integrin β3-deficiency on two different tumors in mice 

      Reigstad, Inga; Sortland, Kristina; Skogstrand, Trude; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2016-01-12)

    • Identification of a Blood-Based Protein Biomarker Panel for Lung Cancer Detection 

      El-Khoury, Victoria; Schritz, Anna; Kim, Sang-Yoon; Lesur, Antoine; Sertamo, Katriina; Bernardin, Francois; Petritis, Konstantinos; Pirrotte, Patrick; Selinsky, Cheryl; Whiteaker, Jeffrey R; Zhang, Haizhen; Kennedy, Jacob J; Lin, Chenwei; Lee, Lik Wee; Yan, Ping; Tran, Nhan L; Inge, Landon J; Chalabi, Khaled; Decker, Georges; Bjerkvig, Rolf; Paulovich, Amanda G; Berchem, Guy; Kim, Yeoun Jin (Journal article; Peer reviewed, 2020)
      Lung cancer is the deadliest cancer worldwide, mainly due to its advanced stage at the time of diagnosis. A non-invasive method for its early detection remains mandatory to improve patients’ survival. Plasma levels of 351 ...

    • Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach 

      Dublang, Leire; Underhaug, Jarl; Flydal, Marte Innselset; Velasco-Carneros, Lorea; Maréchal, Jean-Didier; Moro, Fernando; Boyano, Maria Dolores; Martinez, Aurora; Muga, Arturo (Journal article; Peer reviewed, 2021)
      Heat shock protein (Hsp) synthesis is upregulated in a wide range of cancers to provide the appropriate environment for tumor progression. The Hsp110 and Hsp70 families have been associated to cancer cell survival and ...

    • Mass Spectrometry-Based Proteomics Workflows in Cancer Research: The Relevance of Choosing the Right Steps 

      Carrillo Rodriguez, Paula; Selheim, Frode; Valladares, Maria del Carmen Hernandez (Journal article; Peer reviewed, 2023-01-16)
      The qualitative and quantitative evaluation of proteome changes that condition cancer development can be achieved with liquid chromatography–mass spectrometry (LC-MS). LC-MS-based proteomics strategies are carried out ...

    • Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin 

      Biedermann, Julia; Preussler, Mathias; Conde, Marina; Peitzsch, Mirko; Richter, Susan; Wiedemuth, Ralf; Abou-El-Ardat, Khalil; Krüger, Alexander; Meinhardt, Mathias; Schackert, Gabriele; Leenders, William P.J.; Herold-Mende, Christel; Niclou, Simone Pierrette; Bjerkvig, Rolf; Eisenhofer, Graeme; Temme, Achim; Seifert, Michael; Kunz-Schughart, Leoni A.; Schröck, Evelin; Klink, Barbara (Peer reviewed; Journal article, 2019-12-16)
      IDH1R132H (isocitrate dehydrogenase 1) mutations play a key role in the development of low-grade gliomas. IDH1wt converts isocitrate to α-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+), ...

    • Pretreatment of glioblastoma with bortezomib potentiates natural killer cell cytotoxicity through TRAIL/DR5 mediated apoptosis and prolongs animal survival 

      Gras Navarro, Andrea; Espedal, Heidi; Vareecal Joseph, Justin; Moncho, Laura Trachsel; Bahador, Marzieh; Gjertsen, Bjørn Tore; Kristoffersen, Einar Klæboe; Simonsen, Anne; Miletic, Hrvoje; Enger, Per Øyvind; Rahman, Mohummad Aminur; Enger, Martha Chekenya (Peer reviewed; Journal article, 2019-07-17)
      Background: Natural killer (NK) cells are potential effectors in anti-cancer immunotherapy; however only a subset potently kills cancer cells. Here, we examined whether pretreatment of glioblastoma (GBM) with the proteasome ...

    • Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development 

      Larrieu, Claire M.; Storevik, Simon Humberto; Guyon, Joris; Pagano Zottola, Antonio C.; Bouchez, Cyrielle L.; Derieppe, Marie-Alix; Tan, Tuan Zea; Miletic, Hrvoje; Lorens, James; Tronstad, Karl Johan; Daubon, Thomas; Røsland, Gro Vatne (Journal article; Peer reviewed, 2022)
      Glioblastoma (GB) are the most frequent brain cancers. Aggressive growth and limited treatment options induce a median survival of 12–15 months. In addition to highly proliferative and invasive properties, GB cells show ...

    • Temozolomide-induced rna interactome uncovers novel lncrna regulatory loops in glioblastoma 

      Fritah, Sabrina; Muller, Arnaud; Jiang, Wei; Mitra, Ramkrishna; Sarmini, Mohamad; Dieterle, Monika; Golebiewska, Anna; Ye, Tao; van Dyck, Eric; Herold-Mende, Christel; Zhao, Zhongming; Azuaje, Francisco; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020-09-10)
      Resistance to chemotherapy by temozolomide (TMZ) is a major cause of glioblastoma (GBM) recurrence. So far, attempts to characterize factors that contribute to TMZ sensitivity have largely focused on protein-coding genes, ...

    • Tumor-associated macrophages in gliomas—basic insights and treatment opportunities 

      Andersen, Johannes Kaasa; Miletic, Hrvoje; Hossain, Md Jubayer al (Journal article; Peer reviewed, 2022)
      Glioma refers to a group of primary brain tumors which includes glioblastoma (GBM), astrocytoma and oligodendroglioma as major entities. Among these, GBM is the most frequent and most malignant one. The highly infiltrative ...

    • α11β1 integrin is induced in a subset of cancer- associated fibroblasts in desmoplastic tumor stroma and mediates in vitro cell migration 

      Zeltz, Cedric; Alam, Jahedul; Liu, Hengshuo; Erusappan, Pugazendhi M; Hoschuetzky, Heinz; Molven, Anders; Parajuli, Himalaya; Cukierman, Edna; Costea, Daniela Elena; Lu, Ning; Gullberg, Donald (Peer reviewed; Journal article, 2019-06-01)
      Integrin α11β1 is a collagen receptor that has been reported to be overexpressed in the stroma of non-small cell lung cancer (NSCLC) and of head and neck squamous cell carcinoma (HNSCC). In the current study, we further ...