Blar i Department of Biomedicine på tidsskrift "Journal of Experimental & Clinical Cancer Research"

Viser treff 1-4 av 4

    • Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases 

      Bernatz, Simon; Ilina, Elena I.; Devraj, Kavi; Harter, Patrick N.; Mueller, Klaus; Kleber, Sascha; Braun, Yannick; Penski, Cornelia; Renner, Christoph; Halder, Rashi; Jennewein, Lukas; Solbach, Christine; Thorsen, Frits; Pestalozzi, Bernhard C.; Mischo, Axel; Mittelbronn, Michael (Peer reviewed; Journal article, 2019-10-29)
      Background: Breast cancer (BC) is the most frequent malignant tumor in females and the 2nd most common cause of brain metastasis (BM), that are associated with a fatal prognosis. The increasing incidence from 10% up to 40% ...

    • Mechanical stress shapes the cancer cell response to neddylation inhibition 

      Mittler, Frédérique; Obeïd, Patricia; Haguet, Vincent; Allier, Cédric; Gerbaud, Sophie; Rulina, Anastasiia; Gidrol, Xavier; Balakirev, Maxim Y. (Journal article; Peer reviewed, 2022)
      Background The inhibition of neddylation by the preclinical drug MLN4924 represents a new strategy to combat cancer. However, despite being effective against hematologic malignancies, its success in solid tumors, where ...

    • Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination 

      Zhang, Xin; Xu, Ran; Zhang, Chao; Xu, Yangyang; Han, Mingzhi; Huang, Bin; Chen, Anjing; Qiu, Chen; Thorsen, Frits; Prestegarden, Lars; Bjerkvig, Rolf; Wang, Jian; Li, Xingang (Peer reviewed; Journal article, 2017-09-05)
      Background: Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown to enhance the efficacy of radiotherapy for certain solid ...

    • TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein 

      Yang, Xu; Zhang, Yan; Xue, Zhiwei; Hu, Yaotian; Zhou, Wenjing; Xue, Zhiyi; Liu, Xuemeng; Liu, Guowei; Li, Wenjie; Liu, Xiaofei; Li, Xingang; Han, Mingzhi; Wang, Jian (Journal article; Peer reviewed, 2022)
      Background The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM proteins ...