Browsing Department of Biomedicine by Journals "Nucleic Acids Research (NAR)"

Now showing items 1-3 of 3

    • DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids 

      Zhu, Kang; Suskiewicz, Marcin J.; Chatrin, Chatrin; Strømland, Øyvind; Dorsey, Bryan W.; Aucagne, Vincent; Ahel, Dragana; Ahel, Ivan (Journal article; Peer reviewed, 2024)
      Although ubiquitylation had traditionally been considered limited to proteins, the discovery of non-proteinaceous substrates (e.g. lipopolysaccharides and adenosine diphosphate ribose (ADPr)) challenged this perspective. ...

    • Updated protein domain annotation of the PARP protein family sheds new light on biological function 

      Suskiewicz, Marcin J.; Munnur, Deeksha; Strømland, Øyvind; Yang, Ji-Chun; Easton, Laura E.; Chatrin, Chatrin; Zhu, Kang; Baretić, Domagoj; Goffinont, Stéphane; Schuller, Marion; Wu, Wing-Fung; Elkins, Jonathan M.; Ahel, Dragana; Sanyal, Sumana; Neuhaus, David; Ahel, Ivan (Journal article; Peer reviewed, 2023)
      AlphaFold2 and related computational tools have greatly aided studies of structural biology through their ability to accurately predict protein structures. In the present work, we explored AF2 structural models of the 17 ...

    • XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase 

      Sharma, Abhishek; Erasimus, Hélène; Pinto, Lia; Caron, Marie-Christine; Gopaul, Diyavarshini; Peterlini, Thibault; Neumann, Katrin; Nazarov, Petr V.; Fritah, Sabrina; Klink, Barbara; Herold-Mende, Christel C.; Niclou, Simone Pierrette; Pasero, Philippe; Calsou, Patrick; Masson, Jean-Yves; Britton, Sébastien; Van Dyck, Eric (Journal article; Peer reviewed, 2021)
      Replication-associated single-ended DNA double-strand breaks (seDSBs) are repaired predominantly through RAD51-mediated homologous recombination (HR). Removal of the non-homologous end-joining (NHEJ) factor Ku from resected ...