Department of Biomedicine: Recent submissions

Now showing items 221-240 of 710

    • Sex differences in parent–offspring recurrence of attention-deficit/hyperactivity disorder 

      Solberg, Berit Skretting; Hegvik, Tor-Arne; Halmøy, Anne; Skjaerven, Rolv; Engeland, Anders; Haavik, Jan; Klungsøyr, Kari (Journal article; Peer reviewed, 2020)
      Background Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder sharing genetic risk factors with other common psychiatric disorders. However, intergenerational recurrence ...

    • Tumor-penetrating peptide for systemic targeting of Tenascin-C 

      Lingasamy, Prakash; Tobi, Allan; Kurm, Kaarel; Kopanchuk, Sergei; Sudakov, Aleksander; Salumäe, Markko; Rätsep, Tõnu; Asser, Toomas; Bjerkvig, Rolf; Teesalu, Tambet (Journal article; Peer reviewed, 2020)
      Extracellular matrix in solid tumors has emerged as a specific, stable, and abundant target for affinity-guided delivery of anticancer drugs. Here we describe the homing peptide that interacts with the C-isoform of Tenascin-C ...

    • PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin 

      Reed, Rasmus; Kind, Laura; Kaziales, Anna; Varland, Sylvia; Dai, Minglu; Richter, Klaus; Drazic, Adrian; Arnesen, Thomas (Journal article; Peer reviewed, 2020)
      The actin cytoskeleton is of profound importance to cell shape, division, and intracellular force generation. Profilins bind to globular (G-)actin and regulate actin filament formation. Although profilins are well-established ...

    • Suicide gene therapy for the treatment of high-grade glioma: past lessons, present trends, and future prospects 

      Hossain, Jubayer; Marchini, Antonio; Fehse, Boris; Bjerkvig, Rolf; Miletic, Hrvoje (Journal article; Peer reviewed, 2020)
      Suicide gene therapy has represented an experimental cancer treatment modality for nearly 40 years. Among the various cancers experimentally treated by suicide gene therapy, high-grade gliomas have been the most prominent ...

    • AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion 

      Schuster, Anne; Klein, Eliane; Neirinckx, Virginie; Møldrup Knudsen, Arnon; Fabian, Carina; Hau, Ann-Christin; Dieterle, Monika; Oudin, Anaïs; Nazarov, Petr V.; Golebiewska, Anna; Muller, Arnaud; Perez-Hernandez, Daniel; Rhodius, Sophie; Dittmar, Gunnar; Bjerkvig, Rolf; Herold-Mende, Christel; Klink, Barbara; Winther Kristensen, Bjarne; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020)
      The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic ...

    • Epac1 Is Crucial for Maintenance of Endothelial Barrier Function through A Mechanism Partly Independent of Rac1 

      Garcia-Ponce, Alexander; Schuster, Katharina; Døskeland, Stein Ove; Reed, Rolf K.; Curry, Fitz-Roy E.; Wasche, Jens; Radeva, Mariya Y (Journal article; Peer reviewed, 2020)
      Epac1 (exchange protein activated by cAMP) stabilizes the endothelial barrier, but detailed studies are limited by the side effects of pharmacological Epac1 modulators and transient transfections. Here, we compare the key ...

    • Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment 

      Lillebostad, Peder August Gudmundsen; Raasakka, Arne; Hjellbrekke, Silje Johannessen; Patil, Sudarshan; Røstbø, Trude Kvalnes; Hollås, Hanne; Sakya, Siri; Szigetvari, Peter Daniel; Vedeler, Anni; Kursula, Petri (Journal article; Peer reviewed, 2020)
      The functions of the annexin family of proteins involve binding to Ca2+, lipid membranes, other proteins, and RNA, and the annexins share a common folded core structure at the C terminus. Annexin A11 (AnxA11) has a long ...

    • Integrin α11β1 is a receptor for collagen XIII 

      Koivunen, Jarkko; Tu, Hongmin; Kemppainen, Antti; Anbazhagan, Padmanabhan; Finnilä, Mikko A; Saarakkala, Simo; Käpylä, Jarmo; Lu, Ning; Heikkinen, Anne; Juffer, André H; Heino, Jyrki; Gullberg, Donald; Taina, Pihlajaniemi (Journal article; Peer reviewed, 2021)
      Collagen XIII is a conserved transmembrane collagen mainly expressed in mesenchymal tissues. Previously, we have shown that collagen XIII modulates tissue development and homeostasis. Integrins are a family of receptors ...

    • Involvement of the 14-3-3 Gene Family in Autism Spectrum Disorder and Schizophrenia: Genetics, Transcriptomics and Functional Analyses 

      Torrico, Bàrbara; Antón-Galindo, Ester; Fernàndez-Castillo, Noèlia; Rojo-Francàs, Eva; Ghorbani, Sadaf; Pineda-Cirera, Laura; Hervas, Amaia; Rueda, Isabel; Moreno, Estefanía; Fullerton, Janice M.; Casadó, Vicent; Buitelaar, Jan K; Rommelse, Nanda; Franke, Barbara; Reif, Andreas; Chiocchetti, Andreas G; Freitag, Christine; Kleppe, Rune; Haavik, Jan; Toma, Claudio; Cormand, Bru (Journal article; Peer reviewed, 2020)
      The 14-3-3 protein family are molecular chaperones involved in several biological functions and neurological diseases. We previously pinpointed YWHAZ (encoding 14-3-3ζ) as a candidate gene for autism spectrum disorder (ASD) ...

    • Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase 

      Mahootchi, Elaheh; Raasakk, Arne; Luan, Weisha; Muruganandam, Gopinath; Loris, Remy; Haavik, Jan; Kursula, Petri (Journal article; Peer reviewed, 2021)
      Pyridoxal 5́-phosphate (PLP) is an important cofactor for amino acid decarboxylases with many biological functions, including the synthesis of signalling molecules, such as serotonin, dopamine, histamine, γ-aminobutyric ...

    • Attention-deficit/hyperactivity disorder and smoking habits in pregnant women 

      Anderson, Anneli; Hegvik, Tor-Arne; Chen, Qi; Kvalvik, Liv Grimstvedt; Almqvist, Catarina; D'Onofrio, Brian M.; Hartman, Catharina A; Klungsøyr, Kari; Haavik, Jan; Tuvblad, Catherine; Larsson, Henrik (Journal article; Peer reviewed, 2020)
      Background Attention-deficit/hyperactivity disorder (ADHD) has been associated with an increased risk of tobacco smoking, and more difficulties with smoking cessation compared to non-ADHD individuals. Women with ADHD may ...

    • Kinetic and oligomeric study of Leishmania braziliensis nicotinate/ nicotinamide mononucleotide adenylyltransferase 

      Contreras Rodríguez, Luis Ernesto; Ziegler, Mathias; Ramírez Hernández, María Helena (Journal article; Peer reviewed, 2020)
      Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme involved in REDOX reactions and oxidative stress defense systems. Furthermore, NAD is used as substrate by proteins that regulate essential cellular functions ...

    • Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase 

      Alam, Jahedul; Musiime, Moses; Romaine, Andreas; Sawant, Mugdha; Melleby, Arne Olav; Lu, Ning; Eckes, Beate; Christensen, Geir; Gullberg, Donald (Journal article; Peer reviewed, 2020)
      Cell-specific expression of genes offers the possibility to use their promoters to drive expression of Cre-recombinase, thereby allowing for detailed expression analysis using reporter gene systems, cell lineage tracing, ...

    • CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons 

      Esvald, Eli-Eelika; Tuvikene, Jürgen; Sirp, Alex; Patil, Sudarshan; Bramham, Clive R.; Timmusk, Tõnis (Peer reviewed; Journal article, 2020)
      BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating its own expression levels in neurons, forming ...

    • Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis 

      Guldbrandsen, Astrid; Lereim, Ragnhild Reehorst; Jacobsen, Mari; Garberg, Hilde Kristin; Kroksveen, Ann Cathrine; Barsnes, Harald; Berven, Frode (Journal article; Peer reviewed, 2020)
      Background: Verification of cerebrospinal fluid (CSF) biomarkers for multiple sclerosis and other neurological diseases is a major challenge due to a large number of candidates, limited sample material availability, disease ...

    • Maternal pre-pregnancy overweight/obesityand the risk of attention-deficit/hyperactivitydisorder in offspring: a systematic review, meta-analysis and quasi-experimental family-based study 

      Li, Lin; Lagerberg, Tyra; Chang, Zheng; Cortese, Samuele; Rosenqvist, Mina A.; Almqvist, Catarina; D'Onofrio, Brian M.; Hegvik, Tor-Arne; Hartman, Catharina A.; Chen, Qi; Larsson, Henrik (Journal article; Peer reviewed, 2020)
      Previous studies are inconclusive concerning the association between maternal pre-pregnancy overweight/obesity and risk of attention-deficit/hyperactivity disorder (ADHD) in offspring. We therefore conducted a systematic ...

    • Disulfiram, a ferroptosis inducer, triggers lysosomal membrane permeabilization by up-regulating ROS in glioblastoma 

      Qiu, Chen; Zhang, Xin; Huang, Bin; Wang, Shuai; Zhou, Wenjing; Li, Chao; Li, Xingang; Wang, Jian; Yang, Ning (Journal article; Peer reviewed, 2020)
      Introduction: Disulfiram (DSF), a drug used in the treatment of alcoholism since 1948, has been shown to have antitumor properties in various tumor types possibly due to the induction of a type cell death, ferroptosis, and ...

    • Exploiting the potential of commercial digital holographic microscopy by combining it with 3D matrix cell culture assays 

      Hellesvik, Monica; Øye, Hanne; Aksnes, Henriette (Journal article; Peer reviewed, 2020)
      3D cell culture assays are becoming increasingly popular due to their higher resemblance to tissue environment. These provide an increased complexity compared to the growth on 2D surface and therefore allow studies of ...

    • Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue 

      Fosså, Alexander; Smeland, Knut Bjøro; Fluge, Øystein; Tronstad, Karl Johan; Loge, Jon Håvard; Midtun, Øyvind; Ueland, Per Magne; Kiserud, Cecilie E. (Journal article; Peer reviewed, 2020)
      Chronic cancer-related fatigue (CF) is a common and distressing condition in a subset of cancer survivors and common also after successful treatment of malignant lymphoma. The etiology and pathogenesis of CF is unknown, ...

    • N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus 

      Beigl, Tobias; Hellesvik, Monica; Saraste, Jaakko; Arnesen, Thomas; Aksnes, Henriette (Journal article; Peer reviewed, 2020)
      N-alpha-acetyltransferase 80 (NAA80) was recently demonstrated to acetylate the N-terminus of actin, with NAA80 knockout cells showing actin cytoskeleton-related phenotypes, such as increased formation of membrane protrusions ...