Department of Biomedicine: Recent submissions
Now showing items 281-300 of 710
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Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
(Peer reviewed; Journal article, 2019-05-20)Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the extracellular space, through which small transmitter molecules such as ATP can exit. Co-release of polypeptides and hormones like ... -
Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastoma
(Peer reviewed; Journal article, 2019)Background: Dysregulation of immune checkpoint molecules leads to immune evasion in human tumours but has become a viable target for tumour therapy. Here, we examined expression of Herpes virus entry mediator (HVEM), an ... -
Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases
(Peer reviewed; Journal article, 2019-10-29)Background: Breast cancer (BC) is the most frequent malignant tumor in females and the 2nd most common cause of brain metastasis (BM), that are associated with a fatal prognosis. The increasing incidence from 10% up to 40% ... -
Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design
(Peer reviewed; Journal article, 2019-05-08)Golgi α-mannosidase II (GMII) is a glycoside hydrolase playing a crucial role in the N-glycosylation pathway. In various tumour cell lines, the distribution of N-linked sugars on the cell surface is modified and correlates ... -
Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity
(Peer reviewed; Journal article, 2019)The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central ... -
Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC
(Peer reviewed; Journal article, 2019-06-01)Background: Epithelial to mesenchymal transition (EMT) is a well-characterized process of cell plasticity that may involve metabolic rewiring. In cancer, EMT is associated with malignant progression, tumor heterogeneity, ... -
RNA splicing factor USP39 promotes glioma progression by inducing TAZ mRNA maturation
(Peer reviewed; Journal article, 2019)Increasing evidence demonstrates that ubiquitin specific protease 39 (USP39) plays an oncogenic role in various human tumors. Here, using expression analysis of the publicly available Oncomine database, clinical glioma ... -
Degradation of Extracellular NAD+ Intermediates in Cultures of Human HEK293 Cells
(Peer reviewed; Journal article, 2019-11-29)Nicotinamide adenine dinucleotide (NAD) is an essential redox carrier, whereas its degradation is a key element of important signaling pathways. Human cells replenish their NAD contents through NAD biosynthesis from ... -
Deciphering the complex role of thrombospondin-1 in glioblastoma development
(Peer reviewed; Journal article, 2019-03-08)We undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1) to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma (GBM) development. THBS1 was found to be increased ... -
Direct Binding of the Flexible C-Terminal Segment of Periaxin to β4 Integrin Suggests a Molecular Basis for CMT4F
(Peer reviewed; Journal article, 2019-04-09)The process of myelination in the nervous system requires a coordinated formation of both transient and stable supramolecular complexes. Myelin-specific proteins play key roles in these assemblies, which may link membranes ... -
Effective treatment of metastatic melanoma by combining MAPK and PI3K signaling pathway inhibitors
(Peer reviewed; Journal article, 2019-08-29)Malignant melanoma is the most aggressive type of skin cancer and is closely associated with the development of brain metastases. Despite aggressive treatment, the prognosis has traditionally been poor, necessitating ... -
In-depth cerebrospinal fluid quantitative proteome and deglycoproteome analysis: presenting a comprehensive picture of pathways and processes affected by multiple sclerosis
(Peer reviewed; Journal article, 2017)In the current study, we conducted a quantitative in-depth proteome and deglycoproteome analysis of cerebrospinal fluid (CSF) from relapsing-remitting multiple sclerosis (RRMS) and neurological controls using mass spectrometry ... -
OLS Client and OLS Dialog: Open source tools to annotate public omics datasets
(Peer reviewed; Journal article, 2017)The availability of user‐friendly software to annotate biological datasets and experimental details is becoming essential in data management practices, both in local storage systems and in public databases. The Ontology ... -
Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment.
(Peer reviewed; Journal article, 2019)Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder with only symptomatic care available. Genome-wide association (GWA) studies can provide a starting point in the search for novel drug ... -
Antibodies raised against aldehyde-fixed antigens improve sensitivity for postembedding electron microscopy
(Peer reviewed; Journal article, 2019)Background: Antibodies are one of the most important tools in biological research. High specificity and sensitivity of antibodies are crucial to obtain reliable results. Tissue fixed with glutaraldehyde (GA) is commonly ... -
Understanding the interaction between the co-chaperone DNAJC12 and tyrosine hydroxylase
(Master thesis, 2020-06-23) -
Combining microiontophoresis and multiphoton excitation microscopy to investigate neuronal signaling
(Neuromethods, Chapter; Peer reviewed, 2019)Multiphoton excitation (MPE) microscopy allows subcellular structural and functional imaging of neurons and can be combined with techniques for activating postsynaptic receptors at spatial and temporal scales that mimic ... -
Dominant ARL3-related retinitis pigmentosa
(Peer reviewed; Journal article, 2019)Purpose: To clinically and genetically characterise a second family with dominant ARL3-related retinitis pigmentosa due to a specific ARL3 missense variant, p.(Tyr90Cys). Methods: Clinical examination included optical ... -
Serine 19 phosphorylation and 14‐3‐3 binding regulate phosphorylation and dephosphorylation of tyrosine hydroxylase on serine 31 and serine 40
(Peer reviewed; Journal article, 2019-09-17)Multisite phosphorylation and structural flexibility allow for complex regulation of proteins through cellular signaling. Tyrosine hydroxylase (TH), a key enzyme of catecholamine synthesis, is regulated by multiple neuronal ... -
Severe traumatic brain injury in Norway: Impact of age on outcome
(Peer reviewed; Journal article, 2013-04-23)Objective: The aim of this study was to investigate the influence of age on mortality and 3-month outcome in a Norwegian cohort of patients with severe traumatic brain injury (TBI). Methods: Norwegian residents ≥ 16 years ...