Department of Biomedicine: Nye registreringer
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Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder
(Peer reviewed; Journal article, 2015-10-12)Background. Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background ... -
Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of Annexin A2
(Peer reviewed; Journal article, 2015-01-15)Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation and functions are tightly regulated by its post-translational modifications. AnxA2 and its Tyr23-phosphorylated form ... -
Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression
(Peer reviewed; Journal article, 2015-11)Variants in the gene encoding the enzyme glutamic acid decarboxylase like 1 (GADL1) have been associated with response to lithium therapy. Both GADL1 and the related enzyme cysteine sulfinic acid decarboxylase (CSAD) have ... -
Doping knowledge, attitudes, and practices of Ugandan athletes': A cross-sectional study
(Peer reviewed; Journal article, 2015-09-22)Background. Despite the development of advanced drug testing systems, both deliberate and inadvertent doping in sports is increasing in elite, amateur and school sports. As a result, alternative approaches that seek to ... -
The role of Axl in melanoma metastasis
(Master thesis, 2015-05-31)Melanoma is a highly invasive and metastatic cancer, thus understanding the mechanism of melanoma metastasis is a major issue. In our study, the objective is to elucidate the role of the receptor tyrosine kinase Axl in ... -
Novel microscopy-based screening method reveals regulators of contact-dependent intercellular transfer
(Peer reviewed; Journal article, 2015-08-14)Contact-dependent intercellular transfer (codeIT) of cellular constituents can have functional consequences for recipient cells, such as enhanced survival and drug resistance. Pathogenic viruses, prions and bacteria can ... -
Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE
(Peer reviewed; Journal article, 2015-09)Monoamines critically modulate neurophysiological functions affected in several neuropsychiatric disorders. We therefore examined genes encoding key enzymes of catecholamine and serotonin biosynthesis (tyrosine and tryptophan ... -
Arc is a flexible modular protein capable of reversible self-oligomerization
(Peer reviewed; Journal article, 2015)The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ... -
B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion
(Peer reviewed; Journal article, 2015-04)Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ... -
Common variants in the ARC gene are not associated with cognitive abilities
(Peer reviewed; Journal article, 2015-09-03)Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic ... -
A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines
(Peer reviewed; Journal article, 2015-09-08)To facilitate efficient drug delivery to tumor tissue, several nanomaterials have been designed, with combined diagnostic and therapeutic properties. In this work, we carried out fundamental in vitro and in vivo experiments ... -
Tumor interstitial fluid formation, characterization, and clinical implications
(Peer reviewed; Journal article, 2015-05-26)The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase representing the tissue microenvironment. In the present review, we focus on the interstitial ... -
Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults
(Peer reviewed; Journal article, 2015-05-15)Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the assumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles ... -
Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4)
(Peer reviewed; Journal article, 2015-03-24)Tetrahydrobiopterin (BH4) is the natural cofactor of several enzymes widely distributed among eukaryotes, including aromatic amino acid hydroxylases (AAAHs), nitric oxide synthases (NOSs), and alkylglycerol monooxygenase ... -
The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects
(Peer reviewed; Journal article, 2015-03-13)The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents. However, recent studies have raised the concern that selective ... -
Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells
(Peer reviewed; Journal article, 2015-01-09)Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in culture and in tissues. They mediate intercellular communication ranging from electrical signalling to the transfer of organelles. Here, ... -
A rat model of radiation injury in the mandibular area
(Peer reviewed; Journal article, 2015-06-09)Background Radiation technology focuses on delivering the radiation as precisely as possible to the tumor, nonetheless both acute and long-term damage to surrounding normal tissue may develop. Injuries to the surrounding ... -
The extostosin family: Proteins with many functions
(Peer reviewed; Journal article, 2014-04)Heparan sulfates are complex sulfated molecules found in abundance at cell surfaces and in the extracellular matrix. They bind to and influence the activity of a variety of molecules like growth factors, proteases and ... -
Image-based assessment of microvascular function and structure in collagen XV- and XVIII-deficient mice
(Peer reviewed; Journal article, 2014-01)Collagen XV and XVIII are ubiquitous constituents of basement membranes. We aimed to study the physiological roles of these two components of the permeability barrier non-invasively in striated muscle in mice deficient in ... -
Esmolol added in repeated, cold, oxygenated blood cardioplegia improves myocardial function after cardiopulmonary bypass
(Peer reviewed; Journal article, 2015-06)Objective: This study investigated if the β-receptor blocking agent esmolol, added to standard oxygenated blood cardioplegia, improved myocardial function after weaning from bypass. Design: A block-randomized, blinded ...