Department of Biomedicine: Nye registreringer
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Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy
(Peer reviewed; Journal article, 2017)Surgical resection is a standard component of treatment in the clinical management of patients with glioblastoma multiforme (GBM). However, experimental therapies are rarely investigated in the context of tumor debulking ... -
Prevalence and clinical correlates of insomnia in adults with attention-deficit hyperactivity disorder
(Peer reviewed; Journal article, 2017-08)Objective: To investigate the prevalence of insomnia in adults with Attention-deficit hyperactivity disorder (ADHD) and its association with clinical subtypes, current ADHD symptoms, and stimulant treatment. Method: We ... -
Implication of the APP gene in intellectual abilities
(Peer reviewed; Journal article, 2017)Background: Cognitive functions are highly heritable and polygenic, though the source of this genetic influence is unclear. On the neurobiological level, these functions rely on effective neuroplasticity, in which the ... -
GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation
(Peer reviewed; Journal article, 2017-06-16)The selective and neuronal activity-dependent degradation of synaptic proteins appears to be crucial for long-term synaptic plasticity. One such protein is activity-regulated cytoskeleton-associated protein (Arc), which ... -
Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo
(Peer reviewed; Journal article, 2017-05-10)Activity-regulatedcytoskeleton-associated protein (Arc) protein is implicated as a master regulator of long-term forms of synaptic plasticity and memory formation, but the mechanisms controlling Arc protein function are ... -
Effect of nerve injury on the number of dorsal root ganglion neurons and autotomy behavior in adult Bax-deficient mice
(Peer reviewed; Journal article, 2017-08-30)Background: The proapoptotic molecule BAX, plays an important role in mitochondrial apoptotic pathway. Dorsal root ganglion (DRG) neurons depend on neurotrophic factors for survival at early developmental stages. Withdrawal ... -
Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
(Peer reviewed; Journal article, 2017-10-24)Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia ... -
Investigations of the cancer therapeutic and protective effects of warfarin-mediated inhibition of the receptor tyrosine kinase AXL
(Doctoral thesis, 2017-11-17)Cancer is a major health issue all over the world. Cancer related deaths are one of the major causes of deaths, and are in > 90 % of the cases related to metastatic development, and spread of the cancer outside the primary ... -
Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression
(Peer reviewed; Journal article, 2017)Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1−/− mice, but not Epac2−/− mice, have prolonged bleeding time, ... -
Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo.
(Peer reviewed; Journal article, 2017-03-23)Background: DNA methylation is a key modulator of gene expression in mammalian development and cellular differentiation, including neurons. To date, the role of DNA modifications in long-term potentiation (LTP) has not ... -
Diabetic hyperglycemia reduces Ca2+ permeability of extrasynaptic AMPA receptors in AII amacrine cells
(Peer reviewed; Journal article, 2015-09)There is increasing evidence that diabetic retinopathy is a primary neuropathological disorder that precedes the microvascular pathology associated with later stages of the disease. Recently, we found evidence for altered ... -
AMPA receptors at ribbon synapses in the mammalian retina: kinetic models and molecular identity
(Peer reviewed; Journal article, 2018)In chemical synapses, neurotransmitter molecules released from presynaptic vesicles activate populations of postsynaptic receptors that vary in functional properties depending on their subunit composition. Differential ... -
Semi-automatic 3D morphological reconstruction of neurons with densely branching morphology: Application to retinal AII amacrine cells imaged with multi-photon excitation microscopy
(Peer reviewed; Journal article, 2017-03)Background: Accurate reconstruction of the morphology of single neurons is important for morphometric studies and for developing compartmental models. However, manual morphological reconstruction can be extremely time-consuming ... -
Functional NMDA receptors are expressed by both AII and A17 amacrine cells in the rod pathway of the mammalian retina
(Journal article, 2016-01)At many glutamatergic synapses, non-N-methyl-d-aspartate (NMDA) and NMDA receptors are coexpressed postsynaptically. In the mammalian retina, glutamatergic rod bipolar cells are presynaptic to two rod amacrine cells (AII ... -
Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus
(Peer reviewed; Journal article, 2015-04)Diabetes leads to dysfunction of the neural retina before and independent of classical microvascular diabetic retinopathy, but previous studies have failed to demonstrate which neurons and circuits are affected at the ... -
Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats
(Peer reviewed; Journal article, 2017-10-04)Better understanding of the physiological mechanisms and neurological symptoms involved in the development of decompression sickness could contribute to improvements of diving procedures. The main objective of the present ... -
Electrical synapses between AII amacrine cells in the retina: Function and modulation
(Peer reviewed; Journal article, 2012)Adaptation enables the visual system to operate across a large range of background light intensities. There is evidence that one component of this adaptation is mediated by modulation of gap junctions functioning as ... -
Loss or mislocalization of aquaporin-4 affects diffusion properties and intermediary metabolism in gray matter of mice
(Peer reviewed; Journal article, 2017-01)The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state. Time-dependent ... -
Distributed computing and data storage in proteomics: many hands make light work, and a stronger memory
(Peer reviewed; Journal article, 2014-03)Modern day proteomics generates ever more complex data, causing the requirements on the storage and processing of such data to outgrow the capacity of most desktop computers. To cope with the increased computational demands, ... -
Crowdsourcing in proteomics: public resources lead to better experiments
(Peer reviewed; Journal article, 2013-04)With the growing interest in the field of proteomics, the amount of publicly available proteome resources has also increased dramatically. This means that there are many useful resources available for almost all aspects ...