Department of Biomedicine: Nye registreringer
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Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma
(Peer reviewed; Journal article, 2011-07-29)Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4) or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with an aggressive disease course in several malignancies including ... -
Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer
(Peer reviewed; Journal article, 2011-01-31)Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder, melanoma, pancreas and breast cancer, suggesting that 20q amplification may play a causal role in tumorigenesis. According to an ... -
A New Method for Isolation of Interstitial Fluid from Human Solid Tumors Applied to Proteomic Analysis of Ovarian Carcinoma Tissue
(Peer reviewed; Journal article, 2011-04-26)Major efforts have been invested in the identification of cancer biomarkers in plasma, but the extraordinary dynamic range in protein composition, and the dilution of disease specific proteins make discovery in plasma ... -
Conformational Sampling and Nucleotide-Dependent Transitions of the GroEL Subunit Probed by Unbiased Molecular Dynamics Simulations
(Peer reviewed; Journal article, 2011-03-10)GroEL is an ATP dependent molecular chaperone that promotes the folding of a large number of substrate proteins in E. coli. Large-scale conformational transitions occurring during the reaction cycle have been characterized ... -
Cytokines - possible biomarkers for headache syndromes, with special reference to migraine
(Master thesis, 2011-05-31)Background: The trigeminovascular theory suggests that neurogenic inflammation and cytokines play an important role in migraine pathophysiology. Previous studies have linked different cytokines to migraine pathogenesis, ... -
Brain Computer Interface - Neurophysiology and Experimental Examples
(Master thesis, 2011-07-20)The last century has seen an incredible leap in human medicine, which has led to an increased life expectancy spanning over all age groups. Despite this development of modern medicine some patient groups do not have any ... -
The role of the intermediate compartment in membrane traffic during different stages of the cell cycle
(Master thesis, 2011-06-01)The biosynthetic-secretory pathway delivers newly synthesized molecules from the endoplasmic reticulum (ER) to the plasma membrane (PM), as well as to endomembrane compartments. The intermediate compartment (IC) is an ... -
Attention Network Test in adults with ADHD - the impact of affective fluctuations
(Peer reviewed; Journal article, 2011-07-27)Background: The Attention Network Test (ANT) generates measures of different aspects of attention/executive function. In the present study we investigated whether adults with ADHD performed different from controls on ... -
Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains
(Peer reviewed; Journal article, 2011-01-24)Background: The potential causes for variation in virulence between distinct M. tuberculosis strains are still not fully known. However, differences in protein expression are probably an important factor. In this study we ... -
Neoadjuvant chemotherapy in breast cancer-response evaluation and prediction of response to treatment using dynamic contrast-enhanced and diffusion-weighted MR imaging
(Peer reviewed; Journal article, 2011)Objective To explore the predictive value of MRI parameters and tumour characteristics before neoadjuvant chemotherapy (NAC) and to compare changes in tumour size and tumour apparent diffusion coefficient (ADC) during ... -
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma
(Peer reviewed; Journal article, 2011-08-24)Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer ... -
Influence of organ motion on conformal vs. intensity-modulated pelvic radiotherapy for prostate cancer
(Peer reviewed; Journal article, 2008-08-01) -
Exploring and exploiting the potential of pelvic IMRT to spare the bowel
(Doctoral thesis, 2011-10-28) -
Intensity-modulated radiotherapy of pelvic lymph nodes in locally advanced prostate cancer: planning procedures and early experiences
(Peer reviewed; Journal article, 2008-07-15) -
Impact of hypoxia on the expression of cell line markers and behavior of cultured glioma cell lines
(Master thesis, 2011-06-01)Glioblastoma multiforme (GBM) constitute over 50 % of primary brain tumors in adults. The tumor is heterogeneous and highly infiltrative. Its nature makes it extremely aggressive and incurable. Thus, today's treatment ... -
Virtual Source Modelling of Photon Beams for Monte Carlo Based Radiation Therapy Treatment Planning
(Doctoral thesis, 2011-10-13)Modern radiotherapy (RT) techniques such as stereotactic body radiotherapy (SBRT), intensitymodulated radiotherapy (IMRT) or volumetric modulated arc therapy (VMAT) carries the potential of improving the quality of treatment. ... -
Monte Carlo vs. Pencil Beam based optimization of stereotactic lung IMRT
(Peer reviewed; Journal article, 2009-12-12)Background: The purpose of the present study is to compare finite size pencil beam (fsPB) and Monte Carlo (MC) based optimization of lung intensity-modulated stereotactic radiotherapy (lung IMSRT). Materials and methods: ... -
Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma
(Peer reviewed; Journal article, 2009-12-17)Background: Hypoxia is associated with increased resistance to chemo- and radiation-therapy. Hyperoxic treatment (hyperbaric oxygen) has previously been shown to potentiate the effect of some forms of chemotherapy, and ... -
Hyperoxic Treatment Induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model
(Peer reviewed; Journal article, 2009-07-28)Tumor hypoxia is relevant for tumor growth, metabolism and epithelial-to-mesenchymal transition (EMT). We report that hyperbaric oxygen (HBO) treatment induced mesenchymal-to-epithelial transition (MET) in a dimetyl-a-be ... -
Tumor oxygenation - influence on mammary tumor growth, progression and response to chemotherapy
(Doctoral thesis, 2011-04-28)