Browsing Department of Clinical Medicine by Journals "iScience"

Now showing items 1-3 of 3

    • Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson's disease 

      Dick, Fiona; Tysnes, Ole-Bjørn; Alves, Guido Werner; Sanchez Nido, Gonzalo; Tzoulis, Charalampos (Journal article; Peer reviewed, 2023)
      Aberrant proteostasis is thought to be implicated in Parkinson’s disease (PD), but patient-derived evidence is scant. We hypothesized that impaired proteostasis is reflected as altered transcriptome-proteome correlation ...

    • High-fat diet impact on intestinal cholesterol conversion by the microbiota and serum cholesterol levels 

      Bubeck, Alena M.; Urbain, Paul; Horn, Cathrine; Jung, Anna S.; Ferrari, Lisa; Ruple, Hannah K.; Podlesny, Daniel; Zorn, Stefanie; Laupsa-Borge, Johnny; Jensen, Caroline; Lindseth, Inge Andreas; Lied, Gülen Arslan; Dierkes, Jutta; Mellgren, Gunnar; Bertz, Hartmut; Matysik, Silke; Krautbauer, Sabrina; Liebisch, Gerhard; Schoett, Hans-Frieder; Dankel, Simon N; Fricke, W. Florian (Journal article; Peer reviewed, 2023)
      Cholesterol-to-coprostanol conversion by the intestinal microbiota has been suggested to reduce intestinal and serum cholesterol availability, but the relationship between intestinal cholesterol conversion and the gut ...

    • Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson's disease 

      Gaare, Johannes Jernqvist; Dölle, Christian; Brakedal, Brage; Brügger, Kim; Haugarvoll, Kristoffer; Sanchez Nido, Gonzalo; Tzoulis, Charalampos (Journal article; Peer reviewed, 2023)
      Replenishing nicotinamide adenine dinucleotide (NAD) via supplementation of nicotinamide riboside (NR) has been shown to confer neuroprotective effects in models of aging and neurodegenerative diseases, including Parkinson’s ...